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Elena Alberdi Alfonso

Principal Investigator

Elena Alberdi Alfonso

Contact

Email:Elena.Alberdi@ehu.eus

Tel.:(+34) 94 601 8280

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

Our lab aims at deciphering of molecular mechanisms and signaling pathways responsible for oligodendrocyte proliferation, differentiation or damage and their relevance in oligodendrocyte dynamics, myelin remodeling and axonal conduction in Alzheimer´s disease. To this end, we employ a combination of molecular, imaging and electrophysiological approach in isolated cell culture, organotypic slices and acute slices, as well as in Alzheimer´s disease mouse models and brain samples of Alzheimer´s disease patients.

My main research line is amyloid-beta signalling in oligodendrocytes

Publications

  1. A nonlinear meccano for Alzheimer's emergence by amyloid ββ-mediated glutamatergic hyperactivity

    Bonifazi, Giulio; Luchena, Celia; Gaminde-Blasco, Adhara; Ortiz-Sanz, Carolina; Capetillo-Zarate, Estibaliz; Matute, Carlos; Alberdi, Elena; De Pittà, Maurizio
    Neurobiology of Disease (May, 2024) DOI: 10.1016/j.nbd.2024.106473
  2. 27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes

    Alanko, Vilma; Gaminde-Blasco, Adhara; Quintela-López, Tania; Loera-Valencia, Raúl; Solomon, Alina; Björkhem, Ingemar; Cedazo-Minguez, Angel; Maioli, Silvia; Tabacaru, Graziella; Latorre-Leal, María; Matute, Carlos; Kivipelto, Miia; Alberdi, Elena; Sandebring-Matton, Anna
    Glia (Jun, 2023) DOI: 10.1002/glia.24348
  3. Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slices

    Mendiguren, Aitziber; Aostri, Erik; Alberdi, Elena; Pérez-Samartín, Alberto; Pineda, Joseba
    Frontiers in Pharmacology (Sep, 2022) DOI: 10.3389/fphar.2022.956886
  4. Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers

    Ortiz-Sanz, Carolina; Llavero, Francisco; Zuazo-Ibarra, Jone; Balantzategi, Uxue; Quintela-López, Tania; Wyssenbach, Ane; Capetillo-Zarate, Estibaliz; Matute, Carlos; Alberdi, Elena; Zugaza, José L.
    International Journal of Molecular Sciences (May, 2022) DOI: 10.3390/ijms23105747
  5. A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease

    Luchena, Celia; Zuazo-Ibarra, Jone; Valero, Jorge; Matute, Carlos; Alberdi, Elena; Capetillo-Zarate, Estibaliz
    Frontiers in Aging Neuroscience (Apr, 2022) DOI: 10.3389/fnagi.2022.844534
  6. Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease

    Ortiz-Sanz, Carolina; Balantzategi, Uxue; Quintela-López, Tania; Ruiz, Asier; Luchena, Celia; Zuazo-Ibarra, Jone; Capetillo-Zarate, Estibaliz; Matute, Carlos; Zugaza, José L.; Alberdi, Elena
    Cell Death & Disease (Mar, 2022) DOI: 10.1038/s41419-022-04687-y
  7. Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

    Preman, Pranav; Alfonso-Triguero, Maria; Alberdi, Elena; Verkhratsky, Alexei; Arranz, Amaia M.
    Cells (Mar, 2021) DOI: 10.3390/cells10030540