Our lab aims at deciphering of molecular mechanisms and signaling pathways responsible for oligodendrocyte proliferation, differentiation or damage and their relevance in oligodendrocyte dynamics, myelin remodeling and axonal conduction in Alzheimer´s disease. To this end, we employ a combination of molecular, imaging and electrophysiological approach in isolated cell culture, organotypic slices and acute slices, as well as in Alzheimer´s disease mouse models and brain samples of Alzheimer´s disease patients.
My main research line is amyloid-beta signalling in oligodendrocytes
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changesGlia (Jun, 2023) DOI: 10.1002/glia.24348
Functional characterization of cannabidiol effect on the serotonergic neurons of the dorsal raphe nucleus in rat brain slicesFrontiers in Pharmacology (Sep, 2022) DOI: 10.3389/fphar.2022.956886
Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ OligomersInternational Journal of Molecular Sciences (May, 2022) DOI: 10.3390/ijms23105747
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s DiseaseFrontiers in Aging Neuroscience (Apr, 2022) DOI: 10.3389/fnagi.2022.844534
Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s diseaseCell Death & Disease (Mar, 2022) DOI: 10.1038/s41419-022-04687-y
(Review) Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular PathwaysCells (Mar, 2021) DOI: 10.3390/cells10030540