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Amanda Sierra Saavedra

Principal Investigator

Ikerbasque Research Professor

Amanda Sierra Saavedra

Research groups:

Contact

Email:Amanda.Sierra@achucarro.org

Tel.:(+34) 94 601 8136

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

0000-0001-8415-096X

About me

PhD Universidad Complutense de Madrid, 2003

Our laboratory works on the study of microglial cells at the interplay between phagocytosis and inflammation in the diseased brain. The research involves the study of the cellular and molecular mechanisms involved in the regulation of the efficiency of microglial phagocytosis.

Publications

  1. Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5
    Montilla, Alejandro; Zabala, Alazne; Calvo, Ibai; Bosch-Juan, Marina; Tomé-Velasco, Irene; Mata, Paloma; Koster, Mirjam; Sierra, Amanda; Kooistra, Susanne M.; Soria, Federico N.; Eggen, Bart J. L.; Fresnedo, Olatz; Fernández, José Andrés; Tepavcevic, Vanja; Matute, Carlos; Domercq, María
    Cellular and Molecular Life Sciences (Mar, 2025) DOI: 10.1007/s00018-025-05648-2

  2. Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
    Matera, Alessandro; Compagnion, Anne-Claire; [...] Kerr, William G.; Paolicelli, Rosa C.
    Immunity (Jan, 2025) DOI: 10.1016/j.immuni.2024.11.003

  3. Microglia as hunters or gatherers of brain synapses
    Pereira-Iglesias, Marta; Maldonado-Teixido, Joel; Melero, Alejandro; Piriz, Joaquin; Galea, Elena; Ransohoff, Richard M.; Sierra, Amanda
    Nature Neuroscience (Dec, 2024) DOI: 10.1038/s41593-024-01818-w

  4. Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
    Matera, Alessandro; Compagnion, Anne-Claire; [...] Kerr, William G.; Paolicelli, Rosa C.
    Immunity (Dec, 2024) DOI: 10.1016/j.immuni.2024.11.003

  5. A bottom-up approach identifies the antipsychotic and antineoplastic trifluoperazine and the ribose derivative deoxytubercidin as novel microglial phagocytosis inhibitors
    Rodriguez-Iglesias, N.; Paris, I.; Valero, J.; Cañas-Zabala, L.; Carretero, A.; Hatje, K.; Zhang, J.D.; Patsch, C.; Britschgi, M.; Gutbier, S.; Sierra, A.
    GLIA (Oct, 2024) DOI: 10.1002/glia.24637

  6. Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)
    Sierra, Amanda; Miron, Veronique E.; Paolicelli, Rosa C.; Ransohoff, Richard M.
    Cold Spring Harbor Perspectives in Biology (Aug, 2024) DOI: 10.1101/cshperspect.a041366

  7. Interferons: Invited guests at the brain’s gala banquet
    Márquez-Ropero, Mar; Sierra, Amanda
    Neuron (Apr, 2024) DOI: 10.1016/j.neuron.2024.03.010

  8. Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
    Montilla, Alejandro; Zabala, Alazne; Er-Lukowiak, Marco; Rissiek, Björn; Magnus, Tim; Rodriguez-Iglesias, Noelia; Sierra, Amanda; Matute, Carlos; Domercq, María
    Cell Death & Disease (Jan, 2023) DOI: 10.1038/s41419-023-05551-3

  9. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
    Beccari, Sol; Sierra-Torre, Virginia; [...] Plaza-Zabala, Ainhoa; Sierra, Amanda
    Autophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313

  10. Microglia states and nomenclature: A field at its crossroads
    Paolicelli, Rosa C.; Sierra, Amanda; [...] Wu, Long-Jun; Wyss-Coray, Tony
    Neuron (Nov, 2022) DOI: 10.1016/j.neuron.2022.10.020
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