Hasiera » Directory » Amanda Sierra

Amanda Sierra Saavedra

Principal Investigator

Ikerbasque Research Professor

Amanda Sierra Saavedra

Contact

Email:Amanda.Sierra@achucarro.org

Tel.:(+34) 94 601 8136

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

PhD Universidad Complutense de Madrid, 2003

Our laboratory works on the study of microglial cells at the interplay between phagocytosis and inflammation in the diseased brain. The research involves the study of the cellular and molecular mechanisms involved in the regulation of the efficiency of microglial phagocytosis.

Publications

  1. Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis

    Montilla, Alejandro; Zabala, Alazne; Er-Lukowiak, Marco; Rissiek, Björn; Magnus, Tim; Rodriguez-Iglesias, Noelia; Sierra, Amanda; Matute, Carlos; Domercq, María
    Cell Death & Disease (Jan, 2023) DOI: 10.1038/s41419-023-05551-3
  2. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

    Beccari, Sol; Sierra-Torre, Virginia; [...] Plaza-Zabala, Ainhoa; Sierra, Amanda
    Autophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313
  3. Microglia states and nomenclature: A field at its crossroads

    Paolicelli, Rosa C.; Sierra, Amanda; [...] Wu, Long-Jun; Wyss-Coray, Tony
    Neuron (Nov, 2022) DOI: 10.1016/j.neuron.2022.10.020
  4. Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

    Rodríguez-Iglesias, Noelia; Nadjar, Agnes; Sierra, Amanda; Valero, Jorge
    International Journal of Molecular Sciences (Mar, 2022) DOI: 10.3390/ijms23063399
  5. Editorial: Assessing Microglial Function and Identity

    Sierra, Amanda; Paolicelli, Rosa Chiara
    Frontiers in Immunology (Dec, 2021) DOI: 10.3389/fimmu.2021.824866
  6. Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

    Askew, K.; Li, K.; Olmos-Alonso, A.; Garcia-Moreno, F.; Liang, Y.; Richardson, P.; Tipton, T.; Chapman, M.A.; Riecken, K.; Beccari, S.; Sierra, A.; Molnár, Z.; Cragg, M.S.; Garaschuk, O.; Perry, V.H.; Gomez-Nicola, D.
    Cell Reports (Jan, 2017) DOI: 10.1016/j.celrep.2016.12.041
  7. Neuronal Hyperactivity Accelerates Depletion of Neural Stem Cells and Impairs Hippocampal Neurogenesis

    Sierra, Amanda; Martín-Suárez, Soraya; Valcárcel-Martín, Roberto; Pascual-Brazo, Jesús; Aelvoet, Sarah-Ann; Abiega, Oihane; Deudero, Juan J.; Brewster, Amy L.; Bernales, Irantzu; Anderson, Anne E.; Baekelandt, Veerle; Maletić-Savatić, Mirjana; Encinas, Juan M.
    Cell Stem Cell (May, 2015) DOI: 10.1016/j.stem.2015.04.003