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Ana Bernal Chico

Senior Researcher

Ana Bernal Chico



Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

I graduated in Biochemistry at the University of the Basque Country in Leioa (Spain) in 2008. Following a 1-year training period at the Laboratory of Molecular Genetics (Cruces University Hospital), I started my Thesis project at the Laboratory of Neurobiology under the supervision of Dr. Susana Mato and Prof. Carlos Matute. I obtained my Ph.D. in Neuroscience at University of the Basque Country in 2014 and in 2015 I started a postdoctoral training period at the Momentum Laboratory of Molecular Neurobiology under the supervision of Prof. István Katona (Institute of Experimental Medicine, Hungarian Academy of Sciences in Budapest – KOKI/MTA), as a recipient of a postdoctoral grant from the MTA.

In 2016, I was granted a postdoctoral fellowship from the Basque Government, which supported me until January 2020. During my scientific career, I have collaborated in 6 research projects obtained in national and international competitive calls. I am co-author of 9 publications and 21 communications to national and international meetings. My work on the role of MAGL as therapeutic target in multiple sclerosis (Bernal-Chico et al., Glia 2015) has been awarded by the Spanish Society on Cannabinoid Research (SEIC 2014) and the Spanish Glia Network (RGE, III Laia Acarín Award).

I am a regular member of the SEIC, the Federation of European Neuroscience Societies (FENS), the Spanish Neuroscience Society (SENC) and I belong to the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), as well as to Biocruces Bizkaia HRI.


  1. Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells

    Bernal-Chico, Ana; Tepavcevic, Vanja; Manterola, Andrea; Utrilla, Carmen; Matute, Carlos; Mato, Susana
    Glia (Mar, 2022) DOI: 10.1002/glia.24172
  2. Δ9-Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

    Huerga‐Gómez, Alba; Aguado, Tania; Torre, Aníbal Sánchez-de la; Bernal‐Chico, Ana; Matute, Carlos; Mato, Susana; Guzmán, Manuel; Galve‐Roperh, Ismael; Palazuelos, Javier
    Glia (Mar, 2021) DOI: 10.1002/glia.23911
  3. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination

    Moreno-García, Álvaro; Bernal-Chico, Ana; Colomer, Teresa; Rodríguez-Antigüedad, Alfredo; Matute, Carlos; Mato, Susana
    Biomolecules (Aug, 2020) DOI: 10.3390/biom10091228
  4. P2x7 receptors control demyelination and inflammation in the cuprizone model

    Bernal-Chico, Ana; Manterola, Andrea; Cipriani, Raffaela; Katona, István; Matute, Carlos; Mato, Susana
    Brain, Behavior, & Immunity - Health (Apr, 2020) DOI: 10.1016/j.bbih.2020.100062
  5. Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

    Manterola, Andrea; Bernal-Chico, Ana; Cipriani, Raffaela; Canedo-Antelo, Manuel; Moreno-García, Álvaro; Martín-Fontecha, Mar; Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Ortega-Gutiérrez, Silvia; Brown, J. Mark; Hsu, Ku-Lung; Cravatt, Benjamin; Matute, Carlos; Mato, Susana
    Biochemical Pharmacology (Nov, 2018) DOI: 10.1016/j.bcp.2018.07.042
  6. Cytosolic zinc accumulation contributes to excitotoxic oligodendroglial death: Zinc Mediates AMPA Toxicity to Oligodendrocytes

    Mato, Susana; Sánchez-Gómez, María Victoria; Bernal-Chico, Ana; Matute, Carlos
    GLIA (May, 2013) DOI: 10.1002/glia.22470