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The PIWI Pathway in Lifelong neurogenesis and neuroinflammation

Davide De Pietri Tonelli

Istituto Italiano di Tecnologia (Italy)

24 Mar 2023 13:00

Aketxe Room, Sede Building, Leioa

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Adult NSCs (aNSC) ensure lifelong neurogenesis in the mammalian hippocampus. Proper regulation of aNSC fate entails important implications for brain plasticity and healthy aging. Three decades after microRNA (miRNA) discovery several studies have demonstrated the importance of miRNA-mediated gene regulations in aNSC fate and adult neurogenesis. However, other classes of small noncoding RNA (sncRNA) have been recently found, but their roles in aNSCs are largely unknown. A deeper knowledge of these sncRNAs in aNSCs is paramount for a better mechanistic understanding of brain plasticity, healthy aging, and their use for therapeutic purposes.

In my talk, I will introduce sncRNAs in the context of hippocampal neurogenesis. Next, I will show our recent results related to the role of Piwil2 and Piwi-interacting RNAs (piRNAs) in adult neurogenesis and neuroinflammation. The relevance of these results and their potential implications for successful brain ageing will be discussed.

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