Aging is the main risk factor for Alzheimer disease (AD). Although, it is considered a main non-modifiable risk factor, the reversion of aged to younger cells has been reported in peripheral tissues and, more recently, it has been published a preliminary report on reprogramming old dentate gyrus cells by using the well-known Yamanaka factors.

On the other hand, in the specific neuronal aging, specific neuronal proteins, like tau protein, may play a role. This role and the specific features for neuronal aging will be also discussed.

https://www.researchgate.net/scientific-contributions/Jesus-Avila-39265272