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Susana Mato

Senior Researcher

Susana Mato

Research groups:

Contact

Email:Susana.Mato@ehu.eus

Tel.:(+34) 94601 5681

Faculty of Medicine and Nursery, Department of Neuroscience
Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

Research Interest

My research lines focus on the study of the endocannabinoid system during myelin damage and repair. A main objective of my research activity is to evaluate the involvement of cannabinoid CB1 receptor populations located in glial cells – oligodendrocytes, astrocytes and microglia – in the cellular processes that govern white matter damage/repair and determine their usefulness as possible therapeutic targets in multiple sclerosis.

Experimental Approaches

  • In vivomodels of de- and remyelination (EAE, cuprizone administration)
  • In vitromodels (primary cultures of oligodendrocytes, astrocytes, microglia)
  • Imaging (calcium imaging in cultured cells, confocal microscopy-based imaging)
  • Biochemistry (quantitative PCR, RNA-seq, western blot)
  • Electrophysiology in brain slices (extracellular field recording, patch-clamp in visualized cells)

Research Support

  • Instituto de Salud Carlos III (ISCIII) – Therapeutic relevance of astroglial CB1 receptors in multiple sclerosis (2019-2021)
  • Basque Government – Basic and applied research projects (PIBA) – Endocannabinoid modulation of astroglial and microglial dysfunction in multiple sclerosis (2019-2021)

Collaborators

  • Giovanni Marsicano– Genetic tools for the study of astrocytic and mitochondria CB1 receptors
  • Javier Palazuelos– Biology of oligodendrocytic CB1 receptors
  • Beat Lutz– Transgenic mouse models for the study of CB1 receptors in oligodendrocyte precursors
  • Benjamin F. Cravatt– Pharmacological and genetic tools for ABHD6 blockade
  • Andrés Ozaita – Neurobiology of CB1 receptors in developmental disorders