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Susana Mato Santos

Principal Investigator

Susana Mato Santos



Tel.:(+34) 94 601 5714

Faculty of Medicine and Nursery, Department of Neuroscience
Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

Research Interest

I have devoted my scientific career to deciphering the role of CB 1 receptors in brain pathophysiology using a variety of experimental approaches that include biochemical and radioligand binding methods, electrophysiology, live cell imaging tecnhiques and rodent models of demyelination, among others. A main objective of my research activity is to evaluate the involvement of CB 1R populations located in glial cells in the cellular processes that govern white matter damage/repair and determine their usefulness as therapeutic targets in multiple sclerosis (MS). My work in this field has allowed defining the presence and functional significance of CB 1R in oligodendrocyte populations (Mato et al., Glia 2009; Manterola et al., Front Neuroanat 2022; Sanchez-de-la-Torre et al., Cell Death Dis 2022), the potential of targeting endocannabinoid hydrolysis in MS (Bernal-Chico et al., Glia 2015; Manterola et al., Neuropharmacology 2018) and more recently, the adaptations in endocannabinoid signaling in astrocytes and microglia during autoimmune demyelination (Moreno-García et al., Biomolecules 2020).


  1. Spatial organization of neuron–astrocyte interactions in the somatosensory cortex

    Baraibar, Andrés M; Belisle, Lindsey; Marsicano, Giovanni; Matute, Carlos; Mato, Susana; Araque, Alfonso; Kofuji, Paulo
    Cerebral Cortex (Apr, 2023) DOI: 10.1093/cercor/bhac357
  2. Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse

    Manterola, A.; Chara, J.C.; Aguado, T.; Palazuelos, J.; Matute, C.; Mato, S.
    Frontiers in Neuroanatomy (Oct, 2022) DOI: 10.3389/fnana.2022.1030060
  3. Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

    Sánchez-de la Torre, Aníbal; Aguado, Tania; Huerga-Gómez, Alba; Santamaría, Silvia; Gentile, Antonietta; Chara, Juan Carlos; Matute, Carlos; Monory, Krisztina; Mato, Susana; Guzmán, Manuel; Lutz, Beat; Galve-Roperh, Ismael; Palazuelos, Javier
    Cell Death & Disease (Jul, 2022) DOI: 10.1038/s41419-022-05032-z
  4. Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells

    Bernal-Chico, Ana; Tepavcevic, Vanja; Manterola, Andrea; Utrilla, Carmen; Matute, Carlos; Mato, Susana
    Glia (Mar, 2022) DOI: 10.1002/glia.24172
  5. Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1

    Echeazarra, Leyre; García del Caño, Gontzal; Barrondo, Sergio; González-Burguera, Imanol; Saumell-Esnaola, Miquel; Aretxabala, Xabier; López de Jesús, Maider; Borrega-Román, Leire; Mato, Susana; Ledent, Catherine; Matute, Carlos; Goicolea, María Aranzazu; Sallés, Joan
    Histochemistry and Cell Biology (Aug, 2021) DOI: 10.1007/s00418-021-02025-5
  6. Δ9-Tetrahydrocannabinol promotes functional remyelination in the mouse brain

    Aguado, Tania; Huerga-Gómez, Alba; Torre, Aníbal Sánchez-de la; Resel, Eva; Chara, Juan Carlos; Matute, Carlos; Mato, Susana; Galve-Roperh, Ismael; Guzman, Manuel; Palazuelos, Javier
    British Journal of Pharmacology (Jul, 2021) DOI: 10.1111/bph.15608
  7. Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

    Ramos-Gonzalez, P.; Mato, S.; Chara, J.C.; Verkhratsky, A.; Matute, C.; Cavaliere, F.
    npj Parkinson's Disease (Mar, 2021) DOI: 10.1038/s41531-021-00175-w
  8. Δ9-Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

    Huerga‐Gómez, Alba; Aguado, Tania; Torre, Aníbal Sánchez-de la; Bernal‐Chico, Ana; Matute, Carlos; Mato, Susana; Guzmán, Manuel; Galve‐Roperh, Ismael; Palazuelos, Javier
    Glia (Mar, 2021) DOI: 10.1002/glia.23911
  9. P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

    Calovi, Stefano; Mut-Arbona, Paula; Tod, Pál; Iring, András; Nicke, Annette; Mato, Susana; Vizi, E. Sylvester; Tønnesen, Jan; Sperlagh, Beata
    Frontiers in Molecular Neuroscience (Nov, 2020) DOI: 10.3389/fnmol.2020.566251
  10. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination

    Moreno-García, Álvaro; Bernal-Chico, Ana; Colomer, Teresa; Rodríguez-Antigüedad, Alfredo; Matute, Carlos; Mato, Susana
    Biomolecules (Aug, 2020) DOI: 10.3390/biom10091228