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Pedro Grandes

Group Leader

Full Professor at UPV/EHU

Pedro Grandes



Tel.:(+34) 946 012 875

Faculty of Medicine and Nursery, Department of Neuroscience
Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

Doctor of Medicine and Surgery with Extraordinary Award (UPV/EHU, 1986) and postdoctoral researcher at the Brain Research Institute, University of Zurich (1986-1989). Professor at the UPV / EHU since 1984 and Full Professor of Human Anatomy and Embryology since 2002. He teaches undergraduate courses in Medicine and Postgraduate courses in Neuroscience. He has been secretary (2003-2007) and director of the Department of Neurosciences (UPV / EHU, 2007-2015); member of the Ethics Committee in Research with Biological Agents and Genetically Modified Organisms of the UPV/EHU (2009-2013), of the Board of the Faculty of Medicine and Dentistry (2012-2017) and of the Postgraduate Commission of the UPV/ EHU (2013-2016). He is coordinator of the Interuniversity Doctoral Program in Neurosciences.

Dr. Pedro Grandes is a collaborating researcher at the University of Victoria (Canada). His research deals with the study of the cannabinoid system in the normal and diseased brain (alcoholism, stress, epilepsy, mild head trauma).


  1. The effect of omega-3 fatty acids on alcohol-induced damage

    Serrano, Maitane; Rico-Barrio, Irantzu; Grandes, Pedro
    Frontiers in Nutrition (Apr, 2023)
  2. Target cell-specific plasticity rules of NMDA receptor-mediated synaptic transmission in the hippocampus

    Lutzu, S.; Alviña, K.; Puente, N.; Grandes, P.; Castillo, P.E.
    Frontiers in Cellular Neuroscience (Apr, 2023) DOI: 10.3389/fncel.2023.1068472
  3. Altered glial expression of the cannabinoid 1 receptor in the subiculum of a mouse model of Alzheimer's disease

    Terradillos, Itziar; Bonilla-Del Río, Itziar; Puente, Nagore; Serrano, Maitane; Mimenza, Amaia; Lekunberri, Leire; Anaut-Lusar, Ilazki; Reguero, Leire; Gerrikagoitia, Inmaculada; Ruiz de Martín Esteban, Samuel; Hillard, Cecilia J.; Grande, María T.; Romero, Julián; Elezgarai, Izaskun; Grandes, Pedro
    Glia (In press) DOI: 10.1002/glia.24312
  4. Differential Subcellular Distribution and Release Dynamics of Cotransmitted Cholinergic and GABAergic Synaptic Inputs Modify Dopaminergic Neuronal Excitability

    Gratiet, Keyrian Louis Le; Anderson, Christopher K.; Puente, Nagore; Grandes, Pedro; Copas, Charlotte; Nahirney, Patrick C.; Delaney, Kerry R.; Nashmi, Raad
    Journal of Neuroscience (Nov, 2022) DOI: 10.1523/JNEUROSCI.2514-21.2022
  5. Up-regulation of CB1 cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat

    Echeazarra, Leyre; Barrondo, Sergio; García del Caño, Gontzal; Bonilla-Del Río, Itziar; Egaña-Huguet, Jon; Puente, Nagore; Aretxabala, Xabier; Montaña, Mario; López de Jesús, Maider; González-Burguera, Imanol; Saumell-Esnaola, Miquel; Goicolea, María Aránzazu; Grandes, Pedro; Sallés, Joan
    Frontiers in Neuroanatomy (Oct, 2022) DOI: 10.3389/fnana.2022.1004702
  6. GLAST versus GFAP as astroglial marker for the subcellular study of cannabinoid CB1 receptors in astrocytes

    Achicallende, Svein; Bonilla-Del Río, Itziar; Serrano, Maitane; Mimenza, Amaia; Lekunberri, Leire; Anaut-Lusar, Ilazki; Puente, Nagore; Gerrikagoitia, Inmaculada; Grandes, Pedro
    Histochemistry and Cell Biology (Jul, 2022) DOI: 10.1007/s00418-022-02139-4
  7. Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

    Ruiz de Martín Esteban, Samuel; Benito-Cuesta, Irene; [...] Grande, M. Teresa; Romero, Julián
    Frontiers in Pharmacology (Apr, 2022) DOI: 10.3389/fphar.2022.841766
  8. Cannabinoid control of hippocampal functions: The where matters

    Robledo‐Menendez, Almudena; Vella, Maria; Grandes, Pedro; Soria‐Gomez, Edgar
    The FEBS Journal (Apr, 2022) DOI: 10.1111/febs.15907
  9. The endocannabinoid system in glial cells and their profitable interactions to treat epilepsy: Evidence from animal models

    Egaña-Huguet, J.; Soria-Gómez, E.; Grandes, P.
    International Journal of Molecular Sciences (Dec, 2021) DOI: 10.3390/ijms222413231
  10. Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence

    Rico-Barrio, Irantzu; Peñasco, Sara; Lekunberri, Leire; Serrano, Maitane; Egaña-Huguet, Jon; Mimenza, Amaia; Soria-Gomez, Edgar; Ramos, Almudena; Buceta, Ianire; Gerrikagoitia, Inmaculada; Mendizabal-Zubiaga, Juan; Elezgarai, Izaskun; Puente, Nagore; Grandes, Pedro
    Biomedicines (Jul, 2021) DOI: 10.3390/biomedicines9070825