Ignacio Torres Alemán
Ikerbasque Research Professor
Tel.:(+34) 94 601 8304
Science Park of the UPV/EHU, Sede building
B. Sarriena, s/n
Our lab works on the neurobiology of insulin factors.
We established that IGF-I is a potent neurotrophic factor that plays important roles in brain health and disease and that interacts with insulin in an intricate fashion, in part probably involving hybrid insulin/IGF-I receptors.
More recently, we are interested on circuits involved in the regulation by insulin peptides of mood, cognition and underlying energy requirements within an intricate neuron-glia cross-talk.
Our lab is part of ciberNed, the Spanish Excellence Network of Research on Neurodegenerative Diseases.
Untangling IGF-I signaling in the aging brainAging (Feb, 2023) DOI: 10.18632/aging.204507
Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathologyF1000Research (Dec, 2022) DOI: 10.12688/f1000research.121901.1
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old miceGeroScience (Aug, 2022) DOI: 10.1007/s11357-022-00589-1
Insulin regulates neurovascular coupling through astrocytesProceedings of the National Academy of Sciences (Jul, 2022) DOI: 10.1073/pnas.2204527119
Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin NeuronsInternational Journal of Molecular Sciences (Apr, 2022) DOI: 10.3390/ijms23094679
Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in AgingCells (Feb, 2022) DOI: 10.3390/cells11040717
Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neuronsMolecular Psychiatry (Feb, 2022) DOI: 10.1038/s41380-022-01442-9
Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging MouseFrontiers in Aging Neuroscience (Sep, 2021) DOI: 10.3389/fnagi.2021.682388