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Ignacio Torres Alemán

Group Leader

Ikerbasque Research Professor

Ignacio Torres Alemán



Tel.:(+34) 94 601 8304

Science Park of the UPV/EHU, Sede building
B. Sarriena, s/n
E-48940 Leioa

About me

Our lab works on the neurobiology of insulin factors.

We established that IGF-I is a potent neurotrophic factor that plays important roles in brain health and disease and that interacts with insulin in an intricate fashion, in part probably involving hybrid insulin/IGF-I receptors.

More recently, we are interested on circuits involved in the regulation by insulin peptides of mood, cognition and underlying energy requirements within an intricate neuron-glia cross-talk.

Our lab is part of ciberNed, the Spanish Excellence Network of Research on Neurodegenerative Diseases.


  1. Untangling IGF-I signaling in the aging brain

    Zegarra-Valdivia, Jonathan; Nuñez, Angel; Aleman, Ignacio Torres
    Aging (Feb, 2023) DOI: 10.18632/aging.204507
  2. Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

    Zegarra-Valdivia, Jonathan; Fernandez, Ana M.; Martinez-Rachadell, Laura; Herrero-Labrador, Raquel; Fernandes, Jansen; Aleman, Ignacio Torres
    F1000Research (Dec, 2022) DOI: 10.12688/f1000research.121901.1
  3. Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice

    Zegarra-Valdivia, Jonathan A.; Fernandes, Jansen; Fernandez de Sevilla, Maria Estrella; Trueba-Saiz, Angel; Pignatelli, Jaime; Suda, Kentaro; Martinez-Rachadell, Laura; Fernandez, Ana Maria; Esparza, Julio; Vega, Miguel; Nuñez, Angel; Aleman, Ignacio Torres
    GeroScience (Aug, 2022) DOI: 10.1007/s11357-022-00589-1
  4. Insulin regulates neurovascular coupling through astrocytes

    Fernandez, Ana M.; Martinez-Rachadell, Laura; [...] Gutierrez, Antonia; Torres Aleman, Ignacio
    Proceedings of the National Academy of Sciences (Jul, 2022) DOI: 10.1073/pnas.2204527119
  5. Insulin-like Growth Factor I Couples Metabolism with Circadian Activity through Hypothalamic Orexin Neurons

    Pignatelli, Jaime; de Sevilla, M. Estrella Fernandez; Sperber, Jacob; Horrillo, Daniel; Medina-Gomez, Gema; Torres Aleman, Ignacio
    International Journal of Molecular Sciences (Apr, 2022) DOI: 10.3390/ijms23094679
  6. Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of Mice Was Reduced in Aging

    García-Magro, Nuria; Zegarra-Valdivia, Jonathan A.; Troyas-Martinez, Sara; Torres-Aleman, Ignacio; Nuñez, Angel
    Cells (Feb, 2022) DOI: 10.3390/cells11040717
  7. Insulin-like growth factor I mitigates post-traumatic stress by inhibiting AMP-kinase in orexin neurons

    Fernández de Sevilla, M. Estrella; Pignatelli, Jaime; Zegarra-Valdivia, Jonathan A.; Mendez, Pablo; Nuñez, Angel; Torres Alemán, Ignacio
    Molecular Psychiatry (Feb, 2022) DOI: 10.1038/s41380-022-01442-9
  8. Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

    Zegarra-Valdivia, Jonathan A.; Chaves-Coira, Irene; Fernandez de Sevilla, Maria Estrella; Martinez-Rachadell, Laura; Esparza, Julio; Torres-Aleman, Ignacio; Nuñez, Angel
    Frontiers in Aging Neuroscience (Sep, 2021) DOI: 10.3389/fnagi.2021.682388