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Ignacio Torres Alemán

Principal Investigator

Ikerbasque Research Professor

Ignacio Torres Alemán



Tel.:(+34) 94 601 8304

Science Park of the UPV/EHU, Sede building
B. Sarriena, s/n
E-48940 Leioa

About me

Our lab works on the neurobiology of insulin factors.

We established that IGF-I is a potent neurotrophic factor that plays important roles in brain health and disease and that interacts with insulin in an intricate fashion, in part probably involving hybrid insulin/IGF-I receptors.

More recently, we are interested on circuits involved in the regulation by insulin peptides of mood, cognition and underlying energy requirements within an intricate neuron-glia cross-talk.

Our lab is part of ciberNed, the Spanish Excellence Network of Research on Neurodegenerative Diseases.


  1. A role for astrocytic insulin-like growth factor I receptors in the response to ischemic insult

    Suda, Kentaro; Pignatelli, Jaime; Genis, Laura; Fernandez, Ana M; de Sevilla, Estrella Fernandez; de la Cruz, Ines Fernandez; Pozo-Rodrigalvarez, Andrea; de Ceballos, Maria L; Díaz-Pacheco, Sonia; Herrero-Labrador, Raquel; Aleman, Ignacio Torres
    Journal of Cerebral Blood Flow & Metabolism (Nov, 2023) DOI: 10.1177/0271678X231217669
  2. The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

    Zegarra-Valdivia, Jonathan A.; Pignatelli, Jaime; Nuñez, Angel; Torres Aleman, Ignacio
    International Journal of Molecular Sciences (Nov, 2023) DOI: 10.3390/ijms242216440
  3. Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

    Herrero-Labrador, Raquel; Fernández-Irigoyen, Joaquín; Vecino, Rebeca; González-Arias, Candela; Ausín, Karina; Crespo, Inmaculada; Acosta, Francisco J. Fernández; Nieto-Estévez, Vanesa; Román, M. José; Perea, Gertrudis; Torres-Alemán, Ignacio; Santamaría, Enrique; Vicario, Carlos
    Life Science Alliance (Oct, 2023) DOI: 10.26508/lsa.202201691
  4. The neurobiology of insulin-like growth factor I: From neuroprotection to modulation of brain states | Molecular Psychiatry

    Nuñez, Ángel, Angel; Zegarra-Valdivia, ; Fernandez de Sevilla, ; Pignatelli, Jaime; Torres Alemán, Ignacio
    Molecular Psychiatry (Jun, 2023) DOI: 10.1038/s41380-023-02136-6
  5. Electroactive Materials Surface Charge Impacts Neuron Viability and Maturation in 2D Cultures

    Marques-Almeida, Teresa; Ribeiro, Clarisse; Irastorza, Igor; Miranda-Azpiazu, Patrícia; Torres-Alemán, Ignacio; Silvan, Unai; Lanceros-Méndez, Senentxu
    ACS Applied Materials & Interfaces (Jun, 2023) DOI: 10.1021/acsami.3c04055
  6. Cognitive Deficits in Aging Related to Changes in Basal Forebrain Neuronal Activity

    Chaves-Coira, Irene; García-Magro, Nuria; Zegarra-Valdivia, Jonathan; Torres-Alemán, Ignacio; Núñez, Ángel
    Cells (May, 2023) DOI: 10.3390/cells12111477
  7. Untangling IGF-I signaling in the aging brain

    Zegarra-Valdivia, Jonathan; Nuñez, Angel; Aleman, Ignacio Torres
    Aging (Feb, 2023) DOI: 10.18632/aging.204507
  8. Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

    Zegarra-Valdivia, Jonathan; Fernandez, Ana M.; Martinez-Rachadell, Laura; Herrero-Labrador, Raquel; Fernandes, Jansen; Aleman, Ignacio Torres
    F1000Research (Dec, 2022) DOI: 10.12688/f1000research.121901.1
  9. Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice

    Zegarra-Valdivia, Jonathan A.; Fernandes, Jansen; Fernandez de Sevilla, Maria Estrella; Trueba-Saiz, Angel; Pignatelli, Jaime; Suda, Kentaro; Martinez-Rachadell, Laura; Fernandez, Ana Maria; Esparza, Julio; Vega, Miguel; Nuñez, Angel; Aleman, Ignacio Torres
    GeroScience (Aug, 2022) DOI: 10.1007/s11357-022-00589-1
  10. Insulin regulates neurovascular coupling through astrocytes

    Fernandez, Ana M.; Martinez-Rachadell, Laura; [...] Gutierrez, Antonia; Torres Aleman, Ignacio
    Proceedings of the National Academy of Sciences (Jul, 2022) DOI: 10.1073/pnas.2204527119