Amaia Arranz Mendiguren
Ramón y Cajal Fellow, Ikerbasque Research Fellow
Tel.:(+34) 94 601 8355
Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain
I am currently a Ramon y Cajal and Ikerbasque Research Fellow leading the Laboratory of Humanized Models of Disease.
Our lab aims at unraveling human astrocyte-specific pathways and mechanisms involved in the pathogenesis and progression of AD. Our approaches include the use of humanized in vitro models, chimeric mice and postmortem samples from AD patients that allow exploration of human reactive astrocytes at morphological, molecular, biochemical and functional levels.
hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeuticsMolecular Neurodegeneration (Mar, 2023) DOI: 10.1186/s13024-023-00612-9
Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer’s diseasebioRxiv (In press) DOI: 10.1101/2022.02.18.480849
Evolution of neurogliaAnnals of the New York Academy of Sciences (Dec, 2022) DOI: 10.1111/nyas.14917
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaquesMolecular Neurodegeneration (Sep, 2021) DOI: 10.1186/s13024-021-00487-8
(Review) Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular PathwaysCells (Mar, 2021) DOI: 10.3390/cells10030540