Home » News » New model including glia and neurons to study Alzheimer’s disease

New model including glia and neurons to study Alzheimer’s disease

14 Mar 2022

Glial cells are essential to understand Alzheimer’s disease progression and this model emerges as a powerful tool to study neurodegeneration and inflammation in the context of Alzheimer and other neurodegenerative diseases

The research team led by Ikerbasque researcher Estibaliz Capetillo-Zarate at the Laboratory of Neurobiology of Achucarro Basque Center for Neuroscience and the University of the Basque Country UPV/EHU, has established a straightforward in vitro setting with neurons and glial cells to study Alzheimer´s disease.

Predoctoral researchers, Celia Luchena and Jone Zuazo, together with the rest of the team of this project report a new murine triple co-culture model including neurons, microglia and astrocytes, that holds physiological characteristics that are lost in classical primary cultures. In addition, this model was used to recapitulate amyloid-induced Alzheimer´s disease pathological features like synaptic loss and microglial activation.

Glial cells are essential to understand Alzheimer’s disease progression and this model emerges as a powerful tool to study neurodegeneration and inflammation in the context of Alzheimer and other neurodegenerative diseases.

A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease

Front. Aging Neurosci., 14 April 2022
Sec.Alzheimer’s Disease and Related Dementias
https://doi.org/10.3389/fnagi.2022.844534