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Laboratory of Brain Circuits Therapeutics



Our lab harnesses the power of synthetic biology to understand cognitive processes, motor behavior and disease mechanisms. We are developing an “integrated systems approach” to investigate the role of key players of brain circuits (neurons and glial types) and the extracellular matrix (ECM), especially the perineuronal net. These components are crucial for inter- and extracellular communication and the organization of the “composite” synaptic matrix, that is distributed and interconnected throughout the brain. Major technological advances have been made by our lab for functional mapping of microcircuits and manipulation of brain-wide circuits. More recently, we are developing new technologies for full brain “integrated” and “real-time” activity mapping by magnetic resonance imaging. We are also developing and applying genetic, protein-, lipid- and programmed cellular-based therapeutic strategies to selectively target pathological brain circuits for protection and treatment of neurological and psychiatric diseases in animal models, with potential to treat human diseases in the future.



Cell type specific inducible gene deletion, inducible gene expression systems, two-photon calcium imaging, confocal microscopy, bioluminescence imaging, opto- and pharmacogenetics, synapse labeling, circuit mapping, and different behavioral paradigms, genetic MRI for full brain scale activity mapping.



Principal Investigator

Predoctoral Researcher

Latest publications

  1. Dentate gyrus is needed for memory retrieval

    Carretero-Guillén, Alejandro; Treviño, Mario; Gómez-Climent, María Ángeles; Dogbevia, Godwin K.; Bertocchi, Ilaria; Sprengel, Rolf; Larkum, Matthew E.; Vlachos, Andreas; Gruart, Agnès; Delgado-García, José M.; Hasan, Mazahir T.
    Molecular Psychiatry (Apr, 2024) DOI: 10.1038/s41380-024-02546-0
  2. Pre- and postsynaptic NMDA receptors are required for sequential printing of fear memory engrams

    Bertocchi, Ilaria; Rocha-Almeida, Florbela; Romero-Barragán, María Teresa; Cambiaghi, Marco; Carretero-Guillén, Alejandro; Botta, Paolo; Dogbevia, Godwin K.; Treviño, Mario; Mele, Paolo; Oberto, Alessandra; Larkum, Matthew E.; Gruart, Agnes; Sprengel, Rolf; Delgado-García, José Maria; Hasan, Mazahir T.
    iScience (Nov, 2023) DOI: 10.1016/j.isci.2023.108050
  3. The neurogenetics of functional connectivity alterations in Autism: Insights from subtyping in 657 patients

    Rasero, Javier; Jimenez-Marin, Antonio; Diez, Ibai; Toro, Roberto; Hasan, Mazahir T.; Cortes, Jesus M.
    Biological Psychiatry (Apr, 2023) DOI: 10.1016/j.biopsych.2023.04.014
  4. Advances toward precision therapeutics for developmental and epileptic encephalopathies

    Bertocchi, Ilaria; Cambiaghi, Marco; Hasan, Mazahir T.
    Frontiers in Neuroscience (Apr, 2023) DOI: 10.3389/fnins.2023.1140679
  5. A thalamo-preoptic pathway promotes social grooming in rodents

    Keller, Dávid; Láng, Tamás; Cservenák, Melinda; Puska, Gina; Barna, János; Csillag, Veronika; Farkas, Imre; Zelena, Dóra; Dóra, Fanni; Küppers, Stephanie; Barteczko, Lara; Usdin, Ted B.; Palkovits, Miklós; Hasan, Mazahir T.; Grinevich, Valery; Dobolyi, Arpád
    Current Biology (Nov, 2022) DOI: 10.1016/j.cub.2022.08.062
  6. The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits

    Reus-García, M. Mar; Sánchez-Campusano, Raudel; Ledderose, Julia; Dogbevia, Godwin K.; Treviño, Mario; Hasan, Mazahir T.; Gruart, Agnès; Delgado-García, José M.
    Cerebral Cortex (Jan, 2021) DOI: 10.1093/cercor/bhaa225
  7. Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)

    Colucci, Paola; Marchetta, Enrico; Mancini, Giulia Federica; Alva, Phoebe; Chiarotti, Flavia; Hasan, Mazahir T.; Campolongo, Patrizia
    Translational Psychiatry (Jul, 2020) DOI: 10.1038/s41398-020-00929-9
  8. Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

    Navarrete, Marta; Cuartero, María I.; Palenzuela, Rocío; Draffin, Jonathan E.; Konomi, Ainoa; Serra, Irene; Colié, Sandra; Castaño-Castaño, Sergio; Hasan, Mazahir T.; Nebreda, Ángel R.; Esteban, José A.
    Nature Communications (Jul, 2019) DOI: 10.1038/s41467-019-10830-9
  9. A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System

    Hasan, Mazahir T.; Althammer, Ferdinand; [...] Charlet, Alexandre; Grinevich, Valery
    Neuron (Jul, 2019) DOI: 10.1016/j.neuron.2019.04.029
  10. Cellular cholesterol homeostasis and Alzheimer’s disease

    Chang, Ta-Yuan; Yamauchi, Yoshio; Hasan, Mazahir T.; Chang, Catherine
    Journal of Lipid Research (Dec, 2017) DOI: 10.1194/jlr.R075630