Our lab focuses on using synthetic biology to enhance precision medicine. We have made significant progress in functional mapping of microcircuits, identifying sensory and memory engrams, and accurately manipulating targeted brain circuits to better understand their roles in behavior. We are starting a new project aimed at developing innovative genetic technologies that will enable integrated and real-time activity mapping of the entire brain using magnetic resonance imaging (MRI). These advancements will allow us to observe the dynamics of brain circuits in both healthy and diseased states, as well as after therapeutic interventions in the same subjects. Additionally, we are working on developing and applying adeno-associated viruses (AAVs) and other therapeutic strategies based on proteins, lipids, and induced pluripotent stem cells (iPSCs). Our goal is to repair dysfunctional brain circuits, address neurological and psychiatric disorders, and reverse the effects of aging.