Publications 2016

  1. Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease
    Wyssenbach, Ane; Quintela, Tania; Llavero, Francisco; Zugaza, Jose L.; Matute, Carlos; Alberdi, Elena
    Aging Cell (Dec-16) DOI: 10.1111/acel.12521
  2. The endocytic pathway in microglia during health, aging and Alzheimer's disease
    Solé-Domènech, Santiago; Cruz, Dana L.; Capetillo-Zarate, Estibaliz; Maxfield, Frederick R.
    Ageing Research Reviews (Dec-16) DOI: 10.1016/j.arr.2016.07.002
  3. A role for autophagy in carotid atherosclerosis
    Alloza, Iraide; Goikuria, Haize; Freijo, María del Mar; Vandenbroeck, Koen
    European Stroke Journal (Dec-16) DOI: 10.1177/2396987316674085
  4. Mesenchymal Stem Cells as Therapeutics Agents: Quality and Environmental Regulatory Aspects
    Galvez-Martin, Patricia; Sabata, Roger; Verges, Josep; Zugaza, José L; Ruiz, Adolfina; Clares, Beatriz
    Stem Cells International (Nov-16) DOI: 10.1155/2016/9783408
  5. A cannabinoid link between mitochondria and memory
    Hebert-Chatelain, Etienne; Desprez, Tifany; Serrat, Román; Bellocchio, Luigi; Soria-Gomez, Edgar; Busquets-Garcia, Arnau; Zottola, Antonio Christian Pagano; Delamarre, Anna; Cannich, Astrid; Vincent, Peggy; Varilh, Marjorie; Robin, Laurie M.; Terral, Geoffrey; García-Fernández, M. Dolores; Colavita, Michelangelo; Mazier, Wilfrid; Drago, Filippo; Puente, Nagore; Reguero, Leire; Elezgarai, Izaskun; Dupuy, Jean-William; Cota, Daniela; Lopez-Rodriguez, Maria-Luz; Barreda-Gómez, Gabriel; Massa, Federico; Grandes, Pedro; Bénard, Giovanni; Marsicano, Giovanni
    Nature (Nov-16) DOI: 10.1038/nature20127
  6. Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
    Llavero, Francisco; Artaso, Alain; Lacerda, Hadriano M.; Parada, Luis A.; Zugaza, José L.
    Cellular Signalling (Nov-16) DOI: 10.1016/j.cellsig.2016.07.014
  7. The "Big-Bang" for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia
    Sierra, Amanda; de Castro, Fernando; del Río-Hortega, Juan; Rafael Iglesias-Rozas, José; Garrosa, Manuel; Kettenmann, Helmut
    Glia (Nov-16) DOI: 10.1002/glia.23046
  8. Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
    Mendizabal-Zubiaga, Juan; Melser, Su; Bénard, Giovanni; Ramos, Almudena; Reguero, Leire; Arrabal, Sergio; Elezgarai, Izaskun; Gerrikagoitia, Inmaculada; Suarez, Juan; Rodríguez De Fonseca, Fernando; Puente, Nagore; Marsicano, Giovanni; Grandes, Pedro
    Frontiers in Physiology (Oct-16) DOI: 10.3389/fphys.2016.00476
  9. Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer|[rsquo]|s disease
    Yi, C.; Mei, X.; Ezan, P.; Mato, S.; Matias, I.; Giaume, C.; Koulakoff, A.
    Cell Death & Differentiation (Oct-16) DOI: 10.1038/cdd.2016.63
  10. Clearing the corpses: Regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain
    Diaz-Aparicio, I.; Beccari, S.; Abiega, O.; Sierra, A.
    Neural Regeneration Research (Oct-16) DOI: 10.4103/1673-5374.193220
  11. ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex
    Lalo, U.; Palygin, O.; Verkhratsky, A.; Grant, S. G. N.; Pankratov, Y.
    Scientific Reports (Sep-16) DOI: 10.1038/srep33609
  12. Adenosine A1 receptor inhibits postnatal neurogenesis and sustains astrogliogenesis from the subventricular zone: Adenosine A1 Receptor and Adult Neurogenesis
    Benito-Muñoz, Monica; Matute, Carlos; Cavaliere, Fabio
    Glia (Sep-16) DOI: 10.1002/glia.23010
  13. Translational potential of astrocytes in brain disorders
    Verkhratsky, Alexei; Steardo, Luca; Parpura, Vladimir; Montana, Vedrana
    Progress in Neurobiology (Sep-16) DOI: 10.1016/j.pneurobio.2015.09.003
  14. Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model
    Gomis-González, Maria; Matute, Carlos; Maldonado, Rafael; Mato, Susana; Ozaita, Andrés
    Genes (Aug-16) DOI: 10.3390/genes7090056
  15. Differential control of cocaine self-administration by GABAergic and glutamatergic CB1 cannabinoid receptors
    Martín-García, E.; Bourgoin, L.; Cathala, A.; Kasanetz, F.; Mondesir, M.; Gutiérrez-Rodriguez, A.; Reguero, L.; Fiancette, J.-F.; Grandes, P.; Spampinato, U.; Maldonado, R.; Piazza, P.V.; Marsicano, G.; Deroche-Gamonet, V.
    Neuropsychopharmacology (Aug-16) DOI: 10.1038/npp.2015.351
  16. Calcium and ATP control multiple vital functions
    Petersen, Ole H.; Verkhratsky, Alexei
    Philosophical Transactions of the Royal Society B: Biological Sciences (Aug-16) DOI: 10.1098/rstb.2015.0418
  17. The homeostatic astroglia emerges from evolutionary specialization of neural cells
    Verkhratsky, Alexei; Nedergaard, Maiken
    Phil. Trans. R. Soc. B (Aug-16) DOI: 10.1098/rstb.2015.0428
  18. Inseparable tandem: evolution chooses ATP and Ca2+ to control life, death and cellular signalling
    Plattner, Helmut; Verkhratsky, Alexei
    Phil. Trans. R. Soc. B (Aug-16) DOI: 10.1098/rstb.2015.0419
  19. Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
    Borralleras, Cristina; Mato, Susana; Amédée, Thierry; Matute, Carlos; Mulle, Christophe; Pérez-Jurado, Luis A.; Campuzano, Victoria
    Molecular Brain (Aug-16) DOI: 10.1186/s13041-016-0258-7
  20. Regulation of striatal astrocytic receptor for advanced glycation end‐products variants in an early stage of experimental Parkinson's disease
    Viana, Sofia D.; Valero, Jorge; Rodrigues‐Santos, Paulo; Couceiro, Patrícia; Silva, Andréa M.; Carvalho, Félix; Ali, Syed F.; Fontes‐Ribeiro, Carlos A.; Pereira, Frederico C.
    Journal of Neurochemistry (Aug-16) DOI: 10.1111/jnc.13682
  21. Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment
    Stenovec, Matjaž; Trkov, Saša; Lasič, Eva; Terzieva, Slavica; Kreft, Marko; Rodríguez Arellano, José Julio; Parpura, Vladimir; Verkhratsky, Alexei; Zorec, Robert
    Glia (Aug-16) DOI: 10.1002/glia.22931
  22. Cystine/glutamate antiporter blockage induces myelin degeneration
    Soria, Federico N.; Zabala, Alazne; Pampliega, Olatz; Palomino, Aitor; Miguelez, Cristina; Ugedo, Luisa; Sato, Hideyo; Matute, Carlos; Domercq, María
    Glia (Aug-16) DOI: 10.1002/glia.23011
  23. PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
    Domercq, Maria; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padro, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; Matute, Carlos; Llop, Jordi; Martín, Abraham
    Theranostics (Jul-16) DOI: 10.7150/thno.15616
  24. Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
    Saab, Aiman S.; Tzvetavona, Iva D.; Trevisiol, Andrea; Baltan, Selva; Dibaj, Payam; Kusch, Kathrin; Möbius, Wiebke; Goetze, Bianka; Jahn, Hannah M.; Huang, Wenhui; Steffens, Heinz; Schomburg, Eike D.; Pérez-Samartín, Alberto; Pérez-Cerdá, Fernando; Bakhtiari, Davood; Matute, Carlos; Löwel, Siegrid; Griesinger, Christian; Hirrlinger, Johannes; Kirchhoff, Frank; Nave, Klaus-Armin
    Neuron (Jul-16) DOI: 10.1016/j.neuron.2016.05.016
  25. Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
    Sadovnick, A. Dessa; Traboulsee, Anthony L.; Bernales, Cecily Q.; Ross, Jay P.; Forwell, Amanda L.; Yee, Irene M.; Guillot-Noel, Lena; Fontaine, Bertrand; Cournu-Rebeix, Isabelle; Alcina, Antonio; Fedetz, Maria; Izquierdo, Guillermo; Matesanz, Fuencisla; Hilven, Kelly; Dubois, Bénédicte; Goris, An; Astobiza, Ianire; Alloza, Iraide; Antigüedad, Alfredo; Vandenbroeck, Koen; Akkad, Denis A.; Aktas, Orhan; Blaschke, Paul; Buttmann, Mathias; Chan, Andrew; Epplen, Joerg T.; Gerdes, Lisa-Ann; Kroner, Antje; Kubisch, Christian; Kümpfel, Tania; Lohse, Peter; Rieckmann, Peter; Zettl, Uwe K.; Zipp, Frauke; Bertram, Lars; Lill, Christina M.; Fernandez, Oscar; Urbaneja, Patricia; Leyva, Laura; Alvarez-Cermeño, Jose Carlos; Arroyo, Rafael; Garagorri, Aroa M.; García-Martínez, Angel; Villar, Luisa M.; Urcelay, Elena; Malhotra, Sunny; Montalban, Xavier; Comabella, Manuel; Berger, Thomas; Fazekas, Franz; Reindl, Markus; Schmied, Mascha C.; Zimprich, Alexander; Vilariño-Güell, Carles
    G3: Genes|Genomes|Genetics (Jul-16) DOI: 10.1534/g3.116.030841
  26. The link of inflammation and neurodegeneration in progressive multiple sclerosis
    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos
    Multiple Sclerosis and Demyelinating Disorders (Jul-16) DOI: 10.1186/s40893-016-0012-0
  27. Ionic Signalling in Neuronal-Astroglial Interactions
    Semyanov, Alexey; Verkhratsky, Alexei
    Opera Medica et Physiologica (Jul-16) DOI: 10.20388/OMP2016.002.0030
  28. Pathobiology of Neurodegeneration: The Role for Astroglia
    Verkhratsky, Alexei; Zorec, Robert; Rodriguez, Jose J.; Parpura, Vladimir
    Opera Medica et Physiologica (Jul-16) DOI: 10.20388/OMP2016.001.0019
  29. Targeting astrocytes in bipolar disorder
    Peng, Liang; Li, Baoman; Verkhratsky, Alexei
    Expert Review of Neurotherapeutics (Jun-16) DOI: 10.1586/14737175.2016.1171144
  30. In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis
    Martín, Abraham; Vázquez-Villoldo, Nuria; Gómez-Vallejo, Vanessa; Padro, Daniel; Soria, Federico N.; Szczupak, Boguslaw; Plaza-García, Sandra; Arrieta, Ander; Reese, Torsten; Llop, Jordi; Domercq, Maria; Matute, Carlos
    European Journal of Nuclear Medicine and Molecular Imaging (Jun-16) DOI: 10.1007/s00259-015-3275-3
  31. Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55
    Lopez de Lapuente, Aitzkoa; Feliú, Ana; Ugidos, Nerea; Mecha, Miriam; Mena, Jorge; Astobiza, Ianire; Riera, José; Carillo-Salinas, Francisco; Comabella, Manuel; Montalban, Xavier; Alloza, Iraide; Guaza, Carmen; Vandenbroeck, Koen
    Journal of Immunology (Jun-16) DOI: 10.4049/jimmunol.1501205
  32. Physiology of spontaneous [Ca2+]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus
    Kortus, S.; Srinivasan, C.; Forostyak, O.; Ueta, Y.; Sykova, E.; Chvatal, A.; Zapotocky, M.; Verkhratsky, A.; Dayanithi, G.
    Cell Calcium (Jun-16) DOI: 10.1016/j.ceca.2016.04.001
  33. Sodium-calcium exchanger and R-type Ca2+ channels mediate spontaneous [Ca2+]i oscillations in magnocellular neurones of the rat supraoptic nucleus
    Kortus, S.; Srinivasan, C.; Forostyak, O.; Zapotocky, M.; Ueta, Y.; Sykova, E.; Chvatal, A.; Verkhratsky, A.; Dayanithi, G.
    Cell Calcium (Jun-16) DOI: 10.1016/j.ceca.2016.03.010
  34. Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture
    Zorec, R.; Verkhratsky, A.; Rodríguez, J. J.; Parpura, V.
    Neuroscience (May-16) DOI: 10.1016/j.neuroscience.2015.02.033
  35. Astrocytes in physiological aging and Alzheimer's disease
    Rodríguez-Arellano, J. J.; Parpura, V.; Zorec, R.; Verkhratsky, A.
    Neuroscience (May-16) DOI: 10.1016/j.neuroscience.2015.01.007
  36. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
    Abiega, Oihane; Beccari, Sol; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris, Iñaki; Valero, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco, Maria dM; Matute, Carlos; Maletic-Savatic, Mirjana; Encinas, Juan M.; Sierra, Amanda
    PLOS Biology (May-16) DOI: 10.1371/journal.pbio.1002466
  37. Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina
    Baleriola, Jimena; Álvarez-Lindo, Noemí; Villa, Pedro de la; Bernad, Antonio; Blanco, Luis; Suárez, Teresa; Rosa, Enrique J. de la
    Scientific Reports (May-16) DOI: 10.1038/srep25928
  38. Purinergic neurone-glia signalling in cognitive-related pathologies
    Illes, Peter; Verkhratsky, Alexei
    Neuropharmacology (May-16) DOI: 10.1016/j.neuropharm.2015.08.005
  39. Specific profiles of ion channels and ionotropic receptors define adipose- and bone marrow derived stromal cells
    Forostyak, Oksana; Butenko, Olena; Anderova, Miroslava; Forostyak, Serhiy; Sykova, Eva; Verkhratsky, Alexei; Dayanithi, Govindan
    Stem Cell Research (May-16) DOI: 10.1016/j.scr.2016.03.010
  40. Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis
    Valero, Jorge; Paris, Iñaki; Sierra, Amanda
    ACS Chemical Neuroscience (Apr-16) DOI: 10.1021/acschemneuro.6b00009
  41. Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
    Cavaliere, Fabio; Benito-Muñ Oz, Monica; Matute, Carlos
    Stem Cells International (Apr-16) DOI: 10.1155/2016/3540568
  42. The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis
    Pineda, José R.; Encinas, Juan M.
    Frontiers in Neuroscience (Mar-16) DOI: 10.3389/fnins.2016.00074
  43. Astrocytes: a central element in neurological diseases
    Pekny, Milos; Pekna, Marcela; Messing, Albee; Steinhäuser, Christian; Lee, Jin-Moo; Parpura, Vladimir; Hol, Elly M.; Sofroniew, Michael V.; Verkhratsky, Alexei
    Acta Neuropathologica (Mar-16) DOI: 10.1007/s00401-015-1513-1
  44. Brain local and regional neuroglial alterations in Alzheimer´s Disease: cell types, responses and implications.
    Toledano, Adolfo; Álvarez, María-Isabel; Toledano-Díaz, Adolfo; Merino, José-Joaquín; Rodríguez, José Julio
    Current Alzheimer Research (Mar-16) DOI: 10.2174/1567205013666151116141217
  45. Complex and differential glial responses in Alzheimer´s disease and ageing
    Rodríguez, José; Butt, Arthur; Gardenal, Emanuela; Parpura, Vladimir; Verkhratsky, Alexei
    Current Alzheimer Research (Mar-16) DOI: 10.2174/1567205013666160229112911
  46. Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease
    Lim, Dmitry; Rodríguez-Arellano, J.J; Parpura, Vladimir; Zorec, Robert; Zeidán-Chuliá, Fares; Genazzani, Armando; Verkhratsky, Alexei
    Current Alzheimer Research (Mar-16) DOI: 10.2174/1567205013666151116130104
  47. Physiology of Ca2+ signalling in stem cells of different origins and differentiation stages
    Forostyak, O.; Forostyak, S.; Kortus, S.; Sykova, E.; Verkhratsky, A.; Dayanithi, G.
    Cell Calcium (Mar-16) DOI: 10.1016/j.ceca.2016.02.001
  48. Neuroglia in alzheimer's disease: From cohort to contestant in the disease progression and its therapy
    Toledano, A.; Merino, J.J.; Rodríguez, J.J.
    Current Alzheimer Research (Mar-16) DOI: 10.2174/156720501304160314173258
  49. Calcium signalling in stem cells: Molecular physiology and multiple roles
    Dayanithi, G.; Verkhratsky, A.
    Cell Calcium (Mar-16) DOI: 10.1016/j.ceca.2016.02.006
  50. Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
    Matos, Carlos A.; Nóbrega, Clévio; Louros, Susana R.; Almeida, Bruno; Ferreiro, Elisabete; Valero, Jorge; Pereira de Almeida, Luís; Macedo-Ribeiro, Sandra; Carvalho, Ana Luísa
    Journal of Cell Biology (Feb-16) DOI: 10.1083/jcb.201506025
  51. Rac1/p21‐activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes
    Zaldua, Natalia; Llavero, Francisco; Artaso, Alain; Gálvez, Patricia; Lacerda, Hadriano M.; Parada, Luis A.; Zugaza, José L.
    FEBS Journal (Feb-16) DOI: 10.1111/febs.13617
  52. Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion
    Verkhratsky, Alexei; Matteoli, Michela; Parpura, Vladimir; Mothet, Jean-Pierre; Zorec, Robert
    EMBO Journal (Feb-16) DOI: 10.15252/embj.201592705
  53. Astroglia dynamics in ageing and Alzheimer's disease
    Verkhratsky, Alexei; Zorec, Robert; Rodríguez, Jose J; Parpura, Vladimir
    Current Opinion in Pharmacology (Feb-16) DOI: 10.1016/j.coph.2015.09.011
  54. Axon-to-Glia Interaction Regulates GABAA Receptor Expression in Oligodendrocytes
    Arellano, R. O.; Sanchez-Gomez, M. V.; Alberdi, E.; Canedo-Antelo, M.; Chara, J. C.; Palomino, A.; Perez-Samartin, A.; Matute, C.
    Molecular Pharmacology (Jan-16) DOI: 10.1124/mol.115.100594
  55. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year
    Martinez-Cengotitabengoa, M.; MacDowell, K.S.; Alberich, S.; Diaz, F.J.; Garcia-Bueno, B.; Rodriguez-Jimenez, R.; Bioque, M.; Berrocoso, E.; Parellada, M.; Lobo, A.; Saiz, P.A.; Matute, C.; Bernardo, M.; Gonzalez-Pinto, A.; Leza, J.C.; FLAMM-PEPs
    Schizophrenia Bulletin (Jan-16) DOI: 10.1093/schbul/sbv078
  56. Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
    Verkhratsky, Alexei; Parpura, Vladimir
    Neurobiology of Disease (Jan-16) DOI: 10.1016/j.nbd.2015.03.025
  57. Principles of sodium homeostasis and sodium signalling in astroglia
    Rose, Christine R.; Verkhratsky, Alexei
    Glia (Jan-16) DOI: 10.1002/glia.22964

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