Publications 2016
- The endocytic pathway in microglia during health, aging and Alzheimer's disease
Solé-Domènech, Santiago; Cruz, Dana L.; Capetillo-Zarate, Estibaliz; Maxfield, Frederick R.
Ageing Research Reviews, 2016/12 DOI:10.1016/j.arr.2016.07.002 - Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease
Wyssenbach, Ane; Quintela, Tania; Llavero, Francisco; Zugaza, Jose L.; Matute, Carlos; Alberdi, Elena
Aging Cell, 2016/12 DOI:10.1111/acel.12521 - Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway
Llavero, Francisco; Artaso, Alain; Lacerda, Hadriano M.; Parada, Luis A.; Zugaza, José L.
Cellular Signalling, 2016/11 DOI:10.1016/j.cellsig.2016.07.014 - Clearing the corpses: Regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain (Review)
Diaz-Aparicio, I.; Beccari, S.; Abiega, O.; Sierra, A.
Neural Regeneration Research, 2016/11 DOI:10.4103/1673-5374.193220 - A role for autophagy in carotid atherosclerosis (Review)
Alloza, Iraide; Goikuria, Haize; Freijo, María del Mar; Vandenbroeck, Koen
European Stroke Journal, 2016/10 DOI: 10.1177/2396987316674085 - Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
Mendizabal-Zubiaga, Juan; Melser, Su; Bénard, Giovanni; Ramos, Almudena; Reguero, Leire; Arrabal, Sergio; Elezgarai, Izaskun; Gerrikagoitia, Inmaculada; Suarez, Juan; Rodríguez De Fonseca, Fernando; Puente, Nagore; Marsicano, Giovanni; Grandes, Pedro
Frontiers in Physiology, 2016/10 DOI:10.3389/fphys.2016.00476 - Adenosine A1 receptor inhibits postnatal neurogenesis and sustains astrogliogenesis from the subventricular zone: Adenosine A1 Receptor and Adult Neurogenesis
Benito-Muñoz, Monica; Matute, Carlos; Cavaliere, Fabio
Glia, 2016/09 DOI:10.1002/glia.23010 - Translational potential of astrocytes in brain disorders (Review)
Verkhratsky, Alexei; Steardo, Luca; Parpura, Vladimir; Montana, Vedrana
Progress in Neurobiology, 2016/09 DOI:10.1016/j.pneurobio.2015.09.003 - Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
Borralleras, Cristina; Mato, Susana; Amédée, Thierry; Matute, Carlos; Mulle, Christophe; Pérez-Jurado, Luis A.; Campuzano, Victoria
Molecular Brain, 2016/08 DOI:10.1186/s13041-016-0258-7 - Anatomical characterization of the cannabinoid CB 1 receptor in cell-type-specific mutant mouse rescue models: CB 1 Receptor in Specific Neurons of Mutant Mice
Gutiérrez-Rodríguez, Ana; Puente, Nagore; Elezgarai, Izaskun; Ruehle, Sabine; Lutz, Beat; Reguero, Leire; Gerrikagoitia, Inmaculada; Marsicano, Giovanni; Grandes, Pedro
Journal of Comparative Neurology, 2016/07 DOI:10.1002/cne.24066 - PET Imaging with [18F]FSPG Evidences the Role of System xc- on Brain Inflammation Following Cerebral Ischemia in Rats
Domercq, Maria; Szczupak, Boguslaw; Gejo, Jon; Gómez-Vallejo, Vanessa; Padro, Daniel; Gona, Kiran Babu; Dollé, Frédéric; Higuchi, Makoto; Matute, Carlos; Llop, Jordi; Martín, Abraham
Theranostics, 2016/07 DOI:10.7150/thno.15616 - Physiology of spontaneous [Ca2+]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus
Kortus, S.; Srinivasan, C.; Forostyak, O.; Ueta, Y.; Sykova, E.; Chvatal, A.; Zapotocky, M.; Verkhratsky, A.; Dayanithi, G.
Cell Calcium, 2016/06 DOI:10.1016/j.ceca.2016.04.001 - Sodium-calcium exchanger and R-type Ca2+ channels mediate spontaneous [Ca2+]i oscillations in magnocellular neurones of the rat supraoptic nucleus
Kortus, S.; Srinivasan, C.; Forostyak, O.; Zapotocky, M.; Ueta, Y.; Sykova, E.; Chvatal, A.; Verkhratsky, A.; Dayanithi, G.
Cell Calcium, 2016/06 DOI:10.1016/j.ceca.2016.03.010 - In vivo imaging of system xc- as a novel approach to monitor multiple sclerosis
Martín, Abraham; Vázquez-Villoldo, Nuria; Gómez-Vallejo, Vanessa; Padro, Daniel; Soria, Federico N.; Szczupak, Boguslaw; Plaza-García, Sandra; Arrieta, Ander; Reese, Torsten; Llop, Jordi; Domercq, Maria; Matute, Carlos
European Journal of Nuclear Medicine and Molecular Imaging, 2016/06 DOI:10.1007/s00259-015-3275-3 - Astrocytic face of Alzheimer's disease
Zorec, Robert; Parpura, Vladimir; Vardjan, Nina; Verkhratsky, Alexej
Behavioural Brain Research, 2016/05 DOI:10.1016/j.bbr.2016.05.021 - Purinergic neurone-glia signalling in cognitive-related pathologies (Review)
Illes, Peter; Verkhratsky, Alexei
Neuropharmacology, 2016/05 DOI:10.1016/j.neuropharm.2015.08.005 - Specific profiles of ion channels and ionotropic receptors define adipose- and bone marrow derived stromal cells
Forostyak, Oksana; Butenko, Olena; Anderova, Miroslava; Forostyak, Serhiy; Sykova, Eva; Verkhratsky, Alexei; Dayanithi, Govindan
Stem Cell Research, 2016/05 DOI:10.1016/j.scr.2016.03.010 - Neuroglia in alzheimer's disease: From cohort to contestant in the disease progression and its therapy (Editorial)
Toledano, A.; Merino, J.J.; Rodríguez, J.J.
Current Alzheimer Research, 2016/04 DOI:10.2174/156720501304160314173258 - Astrocytes: a central element in neurological diseases (Review)
Pekny, Milos; Pekna, Marcela; Messing, Albee; Steinhäuser, Christian; Lee, Jin-Moo; Parpura, Vladimir; Hol, Elly M.; Sofroniew, Michael V.; Verkhratsky, Alexei
Acta Neuropathologica, 2016/03 DOI:10.1007/s00401-015-1513-1 - Physiology of Ca2+ signalling in stem cells of different origins and differentiation stages
Forostyak, O.; Forostyak, S.; Kortus, S.; Sykova, E.; Verkhratsky, A.; Dayanithi, G.
Cell Calcium, 2016/03 DOI:10.1016/j.ceca.2016.02.001 - Calcium signalling in stem cells: Molecular physiology and multiple roles (Editorial)
Dayanithi, G.; Verkhratsky, A.
Cell Calcium, 2016/03 DOI:10.1016/j.ceca.2016.02.006 - The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis (Review)
Pineda, José R.; Encinas, Juan M.
Frontiers in Neuroscience, 2016/03 DOI:10.3389/fnins.2016.00074 - Astroglia dynamics in ageing and Alzheimer's disease
Verkhratsky, Alexei; Zorec, Robert; Rodríguez, Jose J; Parpura, Vladimir
Current Opinion in Pharmacology, 2016/02 DOI:10.1016/j.coph.2015.09.011 - Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
Verkhratsky, Alexei; Parpura, Vladimir
Neurobiology of Disease, 2016 DOI:10.1016/j.nbd.2015.03.025 - Mesenchymal Stem Cells as Therapeutics Agents: Quality and Environmental Regulatory Aspects (Review)
Galvez-Martin, Patricia; Sabata, Roger; Verges, Josep; Zugaza, José L; Ruiz, Adolfina; Clares, Beatriz
Stem Cells International, 2016/11 DOI:10.1155/2016/9783408 - A cannabinoid link between mitochondria and memory
Hebert-Chatelain, Etienne; Desprez, Tifany; Serrat, Román; Bellocchio, Luigi; Soria-Gomez, Edgar; Busquets-Garcia, Arnau; Zottola, Antonio Christian Pagano; Delamarre, Anna; Cannich, Astrid; Vincent, Peggy; Varilh, Marjorie; Robin, Laurie M.; Terral, Geoffrey; García-Fernández, M. Dolores; Colavita, Michelangelo; Mazier, Wilfrid; Drago, Filippo; Puente, Nagore; Reguero, Leire; Elezgarai, Izaskun; Dupuy, Jean-William; Cota, Daniela; Lopez-Rodriguez, Maria-Luz; Barreda-Gómez, Gabriel; Massa, Federico; Grandes, Pedro; Bénard, Giovanni; Marsicano, Giovanni
Nature, 2016/11 DOI:10.1038/nature20127 - The "Big-Bang" for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia
Sierra, Amanda; de Castro, Fernando; del Río-Hortega, Juan; Rafael Iglesias-Rozas, José; Garrosa, Manuel; Kettenmann, Helmut
Glia, 2016/11 DOI:10.1002/glia.23046 - Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer|[rsquo]|s disease
Yi, C.; Mei, X.; Ezan, P.; Mato, S.; Matias, I.; Giaume, C.; Koulakoff, A.
Cell Death & Differentiation, 2016/10 DOI:10.1038/cdd.2016.63 - Principles of sodium homeostasis and sodium signalling in astroglia
Rose, Christine R.; Verkhratsky, Alexei
Glia, 2016/10 DOI:10.1002/glia.22964 - ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex
Lalo, U.; Palygin, O.; Verkhratsky, A.; Grant, S. G. N.; Pankratov, Y.
Nature Scientific Reports, 2016/09 DOI:10.1038/srep33609 - Astroglial Vesicular Trafficking in Neurodegenerative Diseases
Zorec, Robert; Parpura, Vladimir; Verkhratsky, Alexei
Neurochemical Research, 2016/09 DOI:10.1007/s11064-016-2055-1 - Possible Therapeutic Doses of Cannabinoid Type 1 Receptor Antagonist Reverses Key Alterations in Fragile X Syndrome Mouse Model
Gomis-González, Maria; Matute, Carlos; Maldonado, Rafael; Mato, Susana; Ozaita, Andrés
Genes, 2016/08 DOI:10.3390/genes7090056 - The homeostatic astroglia emerges from evolutionary specialization of neural cells (Review)
Verkhratsky, Alexei; Nedergaard, Maiken
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016/08 DOI:10.1098/rstb.2015.0428 - Inseparable tandem: evolution chooses ATP and Ca2+ to control life, death and cellular signalling
Plattner, Helmut; Verkhratsky, Alexei
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016/08 DOI:10.1098/rstb.2015.0419 - Calcium and ATP control multiple vital functions
Petersen, Ole H.; Verkhratsky, Alexei
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016/08 DOI:10.1098/rstb.2015.0418 - Cystine/glutamate antiporter blockage induces myelin degeneration
Soria, Federico N.; Zabala, Alazne; Pampliega, Olatz; Palomino, Aitor; Miguelez, Cristina; Ugedo, Luisa; Sato, Hideyo; Matute, Carlos; Domercq, María
Glia, 2016/08 DOI:10.1002/glia.23011 - "Regulation of striatal astrocytic receptor for advanced glycation end‐products variants in an early stage of experimental Parkinson's disease
Viana, Sofia D.; Valero, Jorge; Rodrigues‐Santos, Paulo; Couceiro, Patrícia; Silva, Andréa M.; Carvalho, Félix; Ali, Syed F.; Fontes‐Ribeiro, Carlos A.; Pereira, Frederico C.
Journal of Neurochemistry, 2016/08 DOI:10.1111/jnc.13682 - CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal
Saravia, Rocio; Flores, África; Plaza-Zabala, Ainhoa; Busquets-Garcia, Arnau; Pastor, Antoni; Torre, Rafael de la; Marzo, Vincenzo Di; Marsicano, Giovanni; Ozaita, Andrés; Maldonado, Rafael; Berrendero, Fernando
Biological Psychiatry, 2016/07 DOI:10.1016/j.biopsych.2016.07.007 - Ammonium Increases TRPC1 Expression Via Cav-1/PTEN/AKT/GSK3β Pathway
Wang, Wei; Gu, Li; Verkhratsky, Alexei; Peng, Liang
Neurochemical Research, 2016/07 DOI:10.1007/s11064-016-2004-z - The link of inflammation and neurodegeneration in progressive multiple sclerosis (Review)
Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos
Multiple Sclerosis and Demyelinating Disorders, 2016/07 DOI:10.1186/s40893-016-0012-0 - Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
Saab, Aiman S.; Tzvetavona, Iva D.; Trevisiol, Andrea; Baltan, Selva; Dibaj, Payam; Kusch, Kathrin; Möbius, Wiebke; Goetze, Bianka; Jahn, Hannah M.; Huang, Wenhui; Steffens, Heinz; Schomburg, Eike D.; Pérez-Samartín, Alberto; Pérez-Cerdá, Fernando; Bakhtiari, Davood; Matute, Carlos; Löwel, Siegrid; Griesinger, Christian; Hirrlinger, Johannes; Kirchhoff, Frank; Nave, Klaus-Armin
Neuron, 2016/07 DOI:10.1016/j.neuron.2016.05.016 - Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
Sadovnick, A. Dessa; Traboulsee, Anthony L.; Bernales, Cecily Q.; Ross, Jay P.; Forwell, Amanda L.; Yee, Irene M.; Guillot-Noel, Lena; Fontaine, Bertrand; Cournu-Rebeix, Isabelle; Alcina, Antonio; Fedetz, Maria; Izquierdo, Guillermo; Matesanz, Fuencisla; Hilven, Kelly; Dubois, Bénédicte; Goris, An; Astobiza, Ianire; Alloza, Iraide; Antigüedad, Alfredo; Vandenbroeck, Koen; Akkad, Denis A.; Aktas, Orhan; Blaschke, Paul; Buttmann, Mathias; Chan, Andrew; Epplen, Joerg T.; Gerdes, Lisa-Ann; Kroner, Antje; Kubisch, Christian; Kümpfel, Tania; Lohse, Peter; Rieckmann, Peter; Zettl, Uwe K.; Zipp, Frauke; Bertram, Lars; Lill, Christina M.; Fernandez, Oscar; Urbaneja, Patricia; Leyva, Laura; Alvarez-Cermeño, Jose Carlos; Arroyo, Rafael; Garagorri, Aroa M.; García-Martínez, Angel; Villar, Luisa M.; Urcelay, Elena; Malhotra, Sunny; Montalban, Xavier; Comabella, Manuel; Berger, Thomas; Fazekas, Franz; Reindl, Markus; Schmied, Mascha C.; Zimprich, Alexander; Vilariño-Güell, Carles
G3: Genes|Genomes|Genetics, 2016/07 DOI:10.1534/g3.116.030841 - PLAGL1: an important player in diverse pathological processes
Vega-Benedetti, Ana F.; Saucedo, Cinthia; Zavattari, Patrizia; Vanni, Roberta; Zugaza, José L.; Parada, Luis Antonio
Journal of Applied Genetics, 2016/06 DOI:10.1007/s13353-016-0355-4 - Targeting astrocytes in bipolar disorder (Review)
Peng, Liang; Li, Baoman; Verkhratsky, Alexei
Expert Review of Neurotherapeutics, 2016/06 DOI:10.1586/14737175.2016.1171144 - Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55
Lopez de Lapuente, Aitzkoa; Feliú, Ana; Ugidos, Nerea; Mecha, Miriam; Mena, Jorge; Astobiza, Ianire; Riera, José; Carillo-Salinas, Francisco; Comabella, Manuel; Montalban, Xavier; Alloza, Iraide; Guaza, Carmen; Vandenbroeck, Koen
The Journal of Immunology, 2016/06 DOI:10.4049/jimmunol.1501205 - Astrocytes in physiological aging and Alzheimer's disease
Rodríguez-Arellano, J. J.; Parpura, V.; Zorec, R.; Verkhratsky, A.
Neuroscience, 2016/05 DOI:10.1016/j.neuroscience.2015.01.007 - Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture
Zorec, R.; Verkhratsky, A.; Rodríguez, J. J.; Parpura, V.
Neuroscience, 2016/05 DOI:10.1016/j.neuroscience.2015.02.033 - Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
Abiega, Oihane; Beccari, Sol; Diaz-Aparicio, Irune; Nadjar, Agnes; Layé, Sophie; Leyrolle, Quentin; Gómez-Nicola, Diego; Domercq, María; Pérez-Samartín, Alberto; Sánchez-Zafra, Víctor; Paris, Iñaki; Valero, Jorge; Savage, Julie C.; Hui, Chin-Wai; Tremblay, Marie-Ève; Deudero, Juan J. P.; Brewster, Amy L.; Anderson, Anne E.; Zaldumbide, Laura; Galbarriatu, Lara; Marinas, Ainhoa; Vivanco, Maria dM; Matute, Carlos; Maletic-Savatic, Mirjana; Encinas, Juan M.; Sierra, Amanda
PLOS Biology, 2016/05 DOI:10.1371/journal.pbio.1002466 - Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina
Baleriola, Jimena; Álvarez-Lindo, Noemí; Villa, Pedro de la; Bernad, Antonio; Blanco, Luis; Suárez, Teresa; Rosa, Enrique J. de la
Nature Scientific Reports, 2016/05 DOI:10.1038/srep25928 - Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders (Review)
Cavaliere, Fabio; Benito-Muñ Oz, Monica; Matute, Carlos
Stem Cells International, 2016/04 DOI:10.1155/2016/3540568 - Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study
Mahurkar, S; Moldovan, M; Suppiah, V; Sorosina, M; Clarelli, F; Liberatore, G; Malhotra, S; Montalban, X; Antigüedad, A; Krupa, M; Jokubaitis, V G; McKay, F C; Gatt, P N; Fabis-Pedrini, M J; Martinelli, V; Comi, G; Lechner-Scott, J; Kermode, A G; Slee, M; Taylor, B V; Vandenbroeck, K; Comabella, M; Boneschi, F M; King, C
The Pharmacogenomics Journal, 2016/03 DOI:10.1038/tpj.2016.20 - Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis (Review)
Valero, Jorge; Paris, Iñaki; Sierra, Amanda
ACS Chemical Neuroscience, 2016/03 DOI:10.1021/acschemneuro.6b00009 - Complex and differential glial responses in Alzheimer´s disease and ageing (Review)
Rodríguez, José; Butt, Arthur; Gardenal, Emanuela; Parpura, Vladimir; Verkhratsky, Alexei
Current Alzheimer Research, 2016/03 DOI:10.2174/1567205013666160229112911 - Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's disease
Lim, Dmitry; Rodríguez-Arellano, J.J; Parpura, Vladimir; Zorec, Robert; Zeidán-Chuliá, Fares; Genazzani, Armando; Verkhratsky, Alexei
Current Alzheimer Research, 2016/03 DOI:10.2174/1567205013666151116130104 - Brain local and regional neuroglial alterations in Alzheimer´s Disease: cell types, responses and implications. (Review)
Toledano, Adolfo; Álvarez, María-Isabel; Toledano-Díaz, Adolfo; Merino, José-Joaquín; Rodríguez, José Julio
Current Alzheimer Research, 2016/03 DOI:10.2174/1567205013666151116141217 - Glutamate and ATP at the Interface Between Signaling and Metabolism in Astroglia: Examples from Pathology
Parpura, Vladimir; Fisher, Elizabeth S.; Lechleiter, James D.; Schousboe, Arne; Waagepetersen, Helle S.; Brunet, Sylvain; Baltan, Selva; Verkhratsky, Alexei
Neurochemical Research, 2016/02 DOI:10.1007/s11064-016-1848-6 - Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models
Matos, Carlos A.; Nóbrega, Clévio; Louros, Susana R.; Almeida, Bruno; Ferreiro, Elisabete; Valero, Jorge; Pereira de Almeida, Luís; Macedo-Ribeiro, Sandra; Carvalho, Ana Luísa
The Journal of Cell Biology, 2016/02 DOI:10.1083/jcb.201506025 - Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment
Stenovec, Matjaž; Trkov, Saša; Lasič, Eva; Terzieva, Slavica; Kreft, Marko; Rodríguez Arellano, José Julio; Parpura, Vladimir; Verkhratsky, Alexei; Zorec, Robert
Glia, 2016/02 DOI:10.1002/glia.22931 - Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion (Review)
Verkhratsky, Alexei; Matteoli, Michela; Parpura, Vladimir; Mothet, Jean-Pierre; Zorec, Robert
The EMBO Journal, 2016/02 DOI:10.15252/embj.201592705 - Rac1/p21‐activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes
Zaldua, Natalia; Llavero, Francisco; Artaso, Alain; Gálvez, Patricia; Lacerda, Hadriano M.; Parada, Luis A.; Zugaza, José L.
The FEBS Journal, 2016/02 DOI:10.1111/febs.13617
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