Federico N. Soria
Ramón y Cajal Fellow, Ikerbasque Research Fellow
Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain
After graduating in Argentina (2007), my doctoral thesis in the laboratory of Carlos Matute studied glutamate homeostasis in animal models of brain ischemia and multiple sclerosis.
During my postdoc (2014-2018) at the team of Dr. Erwan Bezard in Bordeaux (France), I co-developed super-resolution imaging techniques to analyze the extracellular compartment in animal models of Parkinson’s disease. These results (Soria et al., 2020 Nat Commun), unraveled the nanoscale organization of the brain extracellular space in pathology and described an unknown feedback loop between the extracellular matrix and microglia. This work set the founding stone for my current research at UPV/EHU and Achucarro, focused on the matrix-glia interplay in healthy, aging and pathological brain, using live imaging and fluorescence microscopy approaches in in vivo, ex vivo and 3D-in vitro paradigms.
Local diffusion in the extracellular space of the brainNeurobiology of Disease (Feb, 2023) DOI: 10.1016/j.nbd.2022.105981
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagyAutophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313
Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal functionAging Cell (Mar, 2022) DOI: 10.1111/acel.13584
Super-resolution STED microscopy in live brain tissueNeurobiology of Disease (Aug, 2021) DOI: 10.1016/j.nbd.2021.105420
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodelingNature Communications (Jul, 2020) DOI: 10.1038/s41467-020-17328-9
Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damageJournal of Clinical Investigation (Aug, 2014) DOI: 10.1172/JCI71886