Mar 31

Subcellular specificity of cannabinoid effects in stratonigral circuits

Edgar Soria-Gomez publishes this article in Neuron, started back in his postdoc in Bordeaux

The recreational and therapeutic uses of cannabinoid compounds are increasing around the world. They have been proposed to control pain sensitivity in clinical settings. However, due to significant side effects, such as cognitive impairments and motor dysfunctions, the medicinal exploitation of these drugs and the safety of their recreational use are under intense debate.  The main psychoactive component of the cannabis sativa (marijuana) plant is delta-9 tetrahydrocannabinol or THC, which, in the brain, acts mainly by activating cannabinoid receptors type-1 (CB1).  The pharmacological activation of the CB1 receptor affects motor control in experimental animals, while in humans the cataleptic effects are considered one of the main causes of traffic accidents due to cannabis use.  Therefore, understanding the mechanisms of cannabinoid-induced therapeutic and adverse effects is vital for the safest use of these compounds, but the underlying cellular and molecular mechanisms are poorly understood.

Ots 26

Garuna gero eta ezagunagoa da, baina ezezaguna da oraindik

Carlos Matuteri elkarrizketa, BERRIA aldizkarian

Jakes Goikoetxea kazetariak, ACHUCARROko Zuzedari Zientifikoa izandako, Carlos Matuteri egindako elkarrizketa ekartzen duzuegu hemen.

Mar 10

Astrocytes in Alzheimer's Disease

A review on their pathological significance and molecular pathways

This review article is fruit of the collaboration between different laboratories and researchers in Achucarro, with Dr. Pranav Preman at VIB-KU Leuven, Belgium.

Mar 24

Cover on ACS Appl Mater Interfaces for a collaboration work on Fluorine Labeling of Nanoparticles

Researcher from Institute Biofisika, CIC biomaGUNE and ACHUCARRO collaborate in this work in the field of molecular imaging

This article shows the results of an amazing collaboration that led to successfully prepare fluorine-labelled nanoparticles (NPs) that are active in 19F magnetic resonance imaging (19F MRI) by either conjugating four different fluorinated building blocks, shown in the 3D structure, to carboxyl-modified NPs or by direct grafting of PEG-fluorinated ligands. The research team obtained 19F MRI images of NPs accumulating in mice livers after intravenous injection.

Mar 16

Achucarro International Glia School 2021 will be on-line

The current edition maintains the core of activities of our training and networking event.

The current situation regarding Covid-19 pandemic restrictions is a major obstacle to organize the 2021 edition of our Glia School in the format we originally planned.

We have therefore decided to switch to an on-line format. This modification implies that poster sessions and practical demonstrations will not take place, while we will maintain the lectures and research project (grant) elaboration including the brainstorming session supervised by the speakers.

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