The lamarckian brain: How your life experience can impact your brain (and that of your children)
EMBO - European Molecular Biology Organization, Germany
The brain is extremely plastic, with all daily experiences and lifestyle having an impact on its short- and long-term function. In recent years it has become apparent that the genome is also very dynamic and plastic and in fact the transcriptome can be used as a read-out of cellular status and homeostasis. Epigenomic and transcriptomic profiling can be very telling of a neuron's or a network's health, activation or disease status. We have taken advantage of sequencing-based technologies to read epitranscriptomic profiles in different mouse models of cognitive decline and have come up with novel therapeutic strategies involving epigenetic regulators. Further to this, we have also shown that certain behavioral and physiological phenotypes elicited by environmental factors can be transmitted across one generation via epigenetic mechanisms.
Host: Amanda Sierra