Ignacio Torres Aleman collaborated with the book entitled “Exercise Brain Stimulation for Cognitive Function and Mental Health”
New insights reveal how physical activity enhances brain-wide protection through IGF-I signaling, opening doors to therapeutic alternatives for neurological conditions.
Physical activity is increasingly recognized not only for its general health benefits but also for its profound impact on brain function. In the absence of effective therapies for many neurological diseases, exercise has emerged as a promising strategy to prevent and even treat these conditions.
Recent research highlights the role of insulin-like growth factor I (IGF-I) as a central mediator of the brain’s response to exercise. IGF-I, a versatile neuroprotective molecule, enters the brain during physical activity and contributes to neurogenesis, cognitive enhancement, and mood regulation. Its powerful anti-apoptotic, anti-inflammatory, and antioxidant properties support brain repair and homeostasis.
Importantly, IGF-I also acts as a messenger between the body and brain, informing neural circuits about muscle and bone status. This interoceptive signaling helps the brain adapt physical activity to available strength and energy, ensuring coordinated and efficient movement.
Understanding these mechanisms is crucial, especially for patients unable to exercise. Researchers are now exploring pharmacological mimics of exercise, aiming to replicate the beneficial effects of IGF-I and offer new therapeutic avenues for brain health.
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