Personal
Contact
Email: susana.mato@ehu.eus
Tel: (+34) 94601 5681
Faculty of Medicine and Nursery, Department of Neuroscience
Barrio Sarriena, s/n
E-48940 Leioa Spain
About me
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Research Interest
My research lines focus on the study of the endocannabinoid system during myelin damage and repair. A main objective of my research activity is to evaluate the involvement of cannabinoid CB1 receptor populations located in glial cells - oligodendrocytes, astrocytes and microglia - in the cellular processes that govern white matter damage/repair and determine their usefulness as possible therapeutic targets in multiple sclerosis.
Experimental Approaches
- In vivo models of de- and remyelination (EAE, cuprizone administration)
- In vitro models (primary cultures of oligodendrocytes, astrocytes, microglia)
- Imaging (calcium imaging in cultured cells, confocal microscopy-based imaging)
- Biochemistry (quantitative PCR, RNA-seq, western blot)
- Electrophysiology in brain slices (extracellular field recording, patch-clamp in visualized cells)
Research Support
- Instituto de Salud Carlos III (ISCIII) - Therapeutic relevance of astroglial CB1 receptors in multiple sclerosis (2019-2021)
- Basque Government - Basic and applied research projects (PIBA) - Endocannabinoid modulation of astroglial and microglial dysfunction in multiple sclerosis (2019-2021)
Collaborators
- Giovanni Marsicano - Genetic tools for the study of astrocytic and mitochondria CB1 receptors
- Javier Palazuelos - Biology of oligodendrocytic CB1 receptors
- Beat Lutz - Transgenic mouse models for the study of CB1 receptors in oligodendrocyte precursors
- Benjamin F. Cravatt - Pharmacological and genetic tools for ABHD6 blockade
- Andrés Ozaita - Neurobiology of CB1 receptors in developmental disorders