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Susana Mato

Senior Researcher

Research group: Laboratory of Neurobiology

Contact

Tel: (+34) 94601 5681

Faculty of Medicine and Nursery, Department of Neuroscience

Barrio Sarriena, s/n

E-48940 Leioa Spain

About me

ORCID  0000-0002-2005-9793   ResearchGate
 

Research Interest

My research lines focus on the study of the endocannabinoid system during myelin damage and repair. A main objective of my research activity is to evaluate the involvement of cannabinoid CB1 receptor populations located in glial cells - oligodendrocytes, astrocytes and microglia - in the cellular processes that govern white matter damage/repair and determine their usefulness as possible therapeutic targets in multiple sclerosis.

Experimental Approaches

  • In vivo models of de- and remyelination (EAE, cuprizone administration)
  • In vitro models (primary cultures of oligodendrocytes, astrocytes, microglia)
  • Imaging (calcium imaging in cultured cells, confocal microscopy-based imaging)
  • Biochemistry (quantitative PCR, RNA-seq, western blot)
  • Electrophysiology in brain slices (extracellular field recording, patch-clamp in visualized cells)

Research Support

  • Instituto de Salud Carlos III (ISCIII) - Therapeutic relevance of astroglial CB1 receptors in multiple sclerosis (2019-2021)
  • Basque Government - Basic and applied research projects (PIBA) - Endocannabinoid modulation of astroglial and microglial dysfunction in multiple sclerosis (2019-2021)

Collaborators

  • Giovanni Marsicano - Genetic tools for the study of astrocytic and mitochondria CB1 receptors
  • Javier Palazuelos - Biology of oligodendrocytic CB1 receptors
  • Beat Lutz - Transgenic mouse models for the study of CB1 receptors in oligodendrocyte precursors
  • Benjamin F. Cravatt - Pharmacological and genetic tools for ABHD6 blockade
  • Andrés Ozaita - Neurobiology of CB1 receptors in developmental disorders