Inicio » Directory » Amaia Arranz

Amaia Arranz Mendiguren

Principal Investigator

Ramón y Cajal Fellow, Ikerbasque Research Associate

Amaia Arranz Mendiguren


Correo electró

Tel.:(+34) 94 601 8355

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

I am currently a Ramon y Cajal and Ikerbasque Research Associate leading the Laboratory of Humanized Models of Disease. 

Our lab aims at unraveling human astrocyte-specific pathways and mechanisms involved in the pathogenesis and progression of AD. Our approaches include the use of humanized in vitro models, chimeric mice and postmortem samples from AD patients that allow exploration of human reactive astrocytes at morphological, molecular, biochemical and functional levels.


  1. A neuron-specific interaction between Alzheimer’s disease risk factors SORL1, APOE, and CLU

    Preman, Pranav; Arranz, Amaia M.
    Cell Reports (Sep, 2023) DOI: 10.1016/j.celrep.2023.113129
  2. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease

    Balusu, Sriram; Horré, Katrien; [...] Fiers, Mark; De Strooper, Bart
    Science (Sep, 2023) DOI: 10.1126/science.abp9556
  3. hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics

    TCW, Julia; Arranz, Amaia M.
    Molecular Neurodegeneration (Mar, 2023) DOI: 10.1186/s13024-023-00612-9
  4. Evolution of neuroglia

    Verkhratsky, Alexei; Arranz, Amaia M.; Ciuba, Katarzyna; Pękowska, Aleksandra
    Annals of the New York Academy of Sciences (Dec, 2022) DOI: 10.1111/nyas.14917
  5. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

    Preman, Pranav; TCW, Julia; Calafate, Sara; Snellinx, An; Alfonso-Triguero, Maria; Corthout, Nikky; Munck, Sebastian; Thal, Dietmar Rudolf; Goate, Alison M.; De Strooper, Bart; Arranz, Amaia M.
    Molecular Neurodegeneration (Sep, 2021) DOI: 10.1186/s13024-021-00487-8
  6. Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

    Preman, Pranav; Alfonso-Triguero, Maria; Alberdi, Elena; Verkhratsky, Alexei; Arranz, Amaia M.
    Cells (Mar, 2021) DOI: 10.3390/cells10030540