Latest Publications
[Updated on Sep 1, 2021]
- Calcium signaling in neuroglia
Lim, D.; Semyanov, A.; Genazzani, A.; Verkhratsky, A.
International Review of Cell and Molecular Biology ((In press)) DOI: 10.1016/bs.ircmb.2021.01.003 - Super-resolution STED microscopy in live brain tissue
Calovi, S.; Soria, F.N.; Tønnesen, J.
Neurobiology of Disease ((In press)) DOI: 10.1016/j.nbd.2021.105420 - A multicentre, randomised, controlled trial of a combined clinical treatment for first-episode psychosis
González-Ortega, I.; Vega, P.; Echeburúa, E.; Alberich, S.; Fernández-Sevillano, J.; Barbeito, S.; Balanzá-Martínez, V.; Vieta, E.; Lorente-Rovira, E.; Luengo, A.; Cerrillo, E.; Crespo, J.M.; Matute, C.; González-Pinto, A.
International Journal of Environmental Research and Public Health ((In press)) DOI: 10.3390/ijerph18147239 - Post-COVID-19 neuropsychiatric syndrome: Is maladaptive glial recovery to blame?
Steardo, L., Jr.; Steardo, L.; Verkhratsky, A.; Scuderi, C.
Acta Physiologica ((In press)) DOI: 10.1111/apha.13717 - Astrocyte arborization enhances Ca2+ but not cAMP signaling plasticity
Pirnat, Samo; Božić, Mićo; Dolanc, Dorian; Horvat, Anemari; Tavčar, Petra; Vardjan, Nina; Verkhratsky, Alexei; Zorec, Robert; Stenovec, Matjaž
Glia ((In press)) DOI: 10.1002/glia.24076 - Transfer of the full SCN1A coding sequence to the brain of adolescent mice model of Dravet syndrome improves epileptic, motor and behavioral manifestations
Mora-Jimenez, Lucia; Valencia, Miguel; Sanchez-Carpintero, Rocio; Tønnesen, Jan; Fadila, Saja; Rubinstein, Moran; Gonzalez-Aparicio, Manuela; Bunuales, Maria; Fernandez-Pierola, Eva; Nicolas, Maria Jesus; Puerta, Elena; Miguelez, Cristina; Minguez, Paula Gimenez; Lumbreras, Sara; Gonzalez-Aseguinolaza, Gloria; Ricobaraza, Ana; Hernandez-Alcoceba, Ruben
Molecular Therapy - Nucleic Acids ((In press)) DOI: 10.1016/j.omtn.2021.08.003 - Coming full circle: In vivo Veritas, or expanding the neuroscience frontier
Khiroug, L.; Verkhratsky, A.
Cell Calcium (Sep-15) DOI: 10.1016/j.ceca.2021.102452 - Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration
Lim, Dmitry; Dematteis, Giulia; Tapella, Laura; Genazzani, Armando A.; Calì, Tito; Brini, Marisa; Verkhratsky, Alexei
Cell Calcium (Sep-01) DOI: 10.1016/j.ceca.2021.102453 - Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
Echeazarra, Leyre; García del Caño, Gontzal; Barrondo, Sergio; González-Burguera, Imanol; Saumell-Esnaola, Miquel; Aretxabala, Xabier; López de Jesús, Maider; Borrega-Román, Leire; Mato, Susana; Ledent, Catherine; Matute, Carlos; Goicolea, María Aranzazu; Sallés, Joan
Histochemistry and Cell Biology (Aug-27) DOI: 10.1007/s00418-021-02025-5 - (Editorial) Cell Signaling in Neurodegeneration
Zugaza, José L.
International Journal of Molecular Sciences (Aug-20) DOI: 10.3390/ijms22168978 - (Editorial) Glial plasticity in health and disease
Majewska, A.K.; Verkhratsky, A.; Hughes, E.G.
European Journal of Neuroscience (Aug-06) DOI: 10.1111/ejn.15414 - Lifestyle-dependent microglial plasticity: training the brain guardians
Augusto-Oliveira, Marcus; Verkhratsky, Alexei
Biology Direct (Aug-05) DOI: 10.1186/s13062-021-00297-4 - Systemic inflammation and neuronal hyperexcitability: Deciphering cellular neuropathology of sickness behaviour
Lin, Si-Si; Verkhratsky, Alexei
Brain, Behavior, and Immunity (Jul-21) DOI: 10.1016/j.bbi.2021.07.013 - Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence
Rico-Barrio, Irantzu; Peñasco, Sara; Lekunberri, Leire; Serrano, Maitane; Egaña-Huguet, Jon; Mimenza, Amaia; Soria-Gomez, Edgar; Ramos, Almudena; Buceta, Ianire; Gerrikagoitia, Inmaculada; Mendizabal-Zubiaga, Juan; Elezgarai, Izaskun; Puente, Nagore; Grandes, Pedro
Biomedicines (Jul-16) DOI: 10.3390/biomedicines9070825 - Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus
Egaña-Huguet, J.; Saumell-Esnaola, M.; Achicallende, S.; Soria-Gomez, E.; Bonilla-Del Río, I.; García del Caño, G.; Barrondo, S.; Sallés, J.; Gerrikagoitia, I.; Puente, N.; Elezgarai, I.; Grandes, P.
Frontiers in Neuroanatomy (Jul-07) DOI: 10.3389/fnana.2021.701573 - Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke
Grayston, Alba; Zhang, Yajie; Garcia-Gabilondo, Miguel; Arrúe, Mercedes; Martin, Abraham; Kopcansky, Peter; Timko, Milan; Kovac, Jozef; Strbak, Oliver; Castellote, Laura; Belloli, Sara; Moresco, Rosa M; Picchio, Maria; Roig, Anna; Rosell, Anna
Journal of Cerebral Blood Flow & Metabolism (Jul-06) DOI: 10.1177/0271678X211028816 - Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons
Bonm, Alipi V.; Elezgarai, Izaskun; Gremel, Christina M.; Viray, Katie; Bamford, Nigel S.; Palmiter, Richard D.; Grandes, Pedro; Lovinger, David M.; Stella, Nephi
European Journal of Neuroscience (Jul-03) DOI: 10.1111/ejn.15381 - Δ9-Tetrahydrocannabinol promotes functional remyelination in the mouse brain
Aguado, Tania; Huerga-Gómez, Alba; Torre, Aníbal Sánchez-de la; Resel, Eva; Chara, Juan Carlos; Matute, Carlos; Mato, Susana; Galve-Roperh, Ismael; Guzman, Manuel; Palazuelos, Javier
British Journal of Pharmacology (Jul-03) DOI: 10.1111/bph.15608 - Local Translation in Nervous System Pathologies
Gamarra, María; de la Cruz, Aida; Blanco-Urrejola, Maite; Baleriola, Jimena
Frontiers in Integrative Neuroscience (Jun-29) DOI: 10.3389/fnint.2021.689208 - Altered Expression of Ion Channels in White Matter Lesions of Progressive Multiple Sclerosis: What Do We Know About Their Function?
Boscia, Francesca; Elkjaer, Maria Louise; Illes, Zsolt; Kukley, Maria
Frontiers in Cellular Neuroscience (Jun-25) DOI: 10.3389/fncel.2021.685703 - Caloric restriction modifies spatiotemporal calcium dynamics in mouse hippocampal astrocytes
Denisov, P.; Popov, A.; Brazhe, A.; Lazareva, N.; Verkhratsky, A.; Semyanov, A.
Biochimica et Biophysica Acta - Molecular Cell Research (Jun-15) DOI: 10.1016/j.bbamcr.2021.119034 - Acute Δ9-tetrahydrocannabinol prompts rapid changes in cannabinoid CB1 receptor immunolabeling and subcellular structure in CA1 hippocampus of young adult male mice
Bonilla-Del Río, I.; Puente, N.; Mimenza, A.; Ramos, A.; Serrano, M.; Lekunberri, L.; Gerrikagoitia, I.; Christie, B.R.; Nahirney, P.C.; Grandes, P.
Journal of Comparative Neurology (Jun-01) DOI: 10.1002/cne.25098 - Regulation of hippocampal postnatal and adult neurogenesis by adenosine A2A receptor: interaction with brain-derived neurotrophic factor
Ribeiro, Filipa F.; Ferreira, Filipa; Rodrigues, Rui S.; Soares, Rita; Pedro, Diogo M.; Duarte-Samartinho, Marta; Aroeira, Rita I.; Ferreiro, Elisabete; Valero, Jorge; Solá, Susana; Mira, Helena; Sebastião, Ana M.; Xapelli, Sara
STEM CELLS (May-27) DOI: https://doi.org/10.1002/stem.3421 - Opposite alterations of 5HT 2A receptor brain density in subjects with schizophrenia: relevance of radiotracers pharmacological profile
Diez-Alarcia, Rebeca; Muguruza, Carolina; Rivero, Guadalupe; García-Bea, Aintzane; Gómez-Vallejo, Vanessa; Callado, Luis F.; Llop, Jordi; Martín, Abraham; Meana, J. Javier
Translational Psychiatry (May-20) DOI: 10.1038/s41398-021-01430-7 - (Review) Early evolutionary history (from bacteria to hemichordata) of the omnipresent purinergic signalling: A tribute to geoff burnstock inquisitive mind
Verkhratsky, Alexei
Biochemical Pharmacology (May-15) DOI: 10.1016/j.bcp.2020.114261 - Cannabinoid control of hippocampal functions: The where matters
Robledo‐Menendez, Almudena; Vella, Maria; Grandes, Pedro; Soria‐Gomez, Edgar
The FEBS Journal (May-11) DOI: https://doi.org/10.1111/febs.15907 - The future belongs to those who prepare for it today
Martín-Suárez, Soraya; Encinas, Juan Manuel
Cell Stem Cell (May-06) DOI: 10.1016/j.stem.2021.04.014 - Subcellular specificity of cannabinoid effects in striatonigral circuits
Soria-Gomez, E.; Pagano Zottola, A.C.; Mariani, Y.; Desprez, T.; Barresi, M.; Bonilla-del Río, I.; Muguruza, C.; Le Bon-Jego, M.; Julio-Kalajzić, F.; Flynn, R.; Terral, G.; Fernández-Moncada, I.; Robin, L.M.; Oliveira da Cruz, J.F.; Corinti, S.; Amer, Y.O.; Goncalves, J.; Varilh, M.; Cannich, A.; Redon, B.; Zhao, Z.; Lesté-Lasserre, T.; Vincent, P.; Tolentino-Cortes, T.; Busquets-García, A.; Puente, N.; Bains, J.S.; Hebert-Chatelain, E.; Barreda-Gómez, G.; Chaouloff, F.; Lohman, A.W.; Callado, L.F.; Grandes, P.; Baufreton, J.; Marsicano, G.; Bellocchio, L.
Neuron (May-05) DOI: 10.1016/j.neuron.2021.03.007 - Iron induces two distinct Ca2+ signalling cascades in astrocytes
Guan, W.; Xia, M.; Ji, M.; Chen, B.; Li, S.; Zhang, M.; Liang, S.; Chen, B.; Gong, W.; Dong, C.; Wen, G.; Zhan, X.; Zhang, D.; Li, X.; Zhou, Y.; Guan, D.; Verkhratsky, A.; Li, B.
Communications Biology (May-05) DOI: 10.1038/s42003-021-02060-x - Connexins as therapeutic targets in neurological and neuropsychiatric disorders
Charvériat, M.; Mouthon, F.; Rein, W.; Verkhratsky, A.
Biochimica et Biophysica Acta - Molecular Basis of Disease (May-01) DOI: 10.1016/j.bbadis.2021.166098 - Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease
Rejc, L.; Gómez-Vallejo, V.; Joya, A.; Moreno, O.; Egimendia, A.; Castellnou, P.; Ríos-Anglada, X.; Cossío, U.; Baz, Z.; Passannante, R.; Tobalina-Larrea, I.; Ramos-Cabrer, P.; Giralt, A.; Sastre, M.; Capetillo-Zarate, E.; Košak, U.; Knez, D.; Gobec, S.; Marder, M.; Martin, A.; Llop, J.
Theranostics (Apr-26) DOI: 10.7150/thno.54589 - (Review) Small gtpases of the rab and arf families: Key regulators of intracellular trafficking in neurodegeneration
Sastre, A.A.; Montoro, M.L.; Lacerda, H.M.; Llavero, F.; Zugaza, J.L.
International Journal of Molecular Sciences (Apr-23) DOI: 10.3390/ijms22094425 - The anti-inflammatory astrocyte revealed: the role of the microbiome in shaping brain defences
Verkhratsky, A.; Illes, P.; Tang, Y.; Semyanov, A.
Signal Transduction and Targeted Therapy (Apr-10) DOI: 10.1038/s41392-021-00577-5 - Astrocytic atrophy as a pathological feature of Parkinson's disease with LRRK2 mutation
Ramos-Gonzalez, P.; Mato, S.; Chara, J.C.; Verkhratsky, A.; Matute, C.; Cavaliere, F.
npj Parkinson's Disease (Mar-30) DOI: 10.1038/s41531-021-00175-w - Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies
Luzuriaga, Jon; Polo, Yurena; Pastor-Alonso, Oier; Pardo-Rodríguez, Beatriz; Larrañaga, Aitor; Unda, Fernando; Sarasua, Jose-Ramon; Pineda, Jose Ramon; Ibarretxe, Gaskon
International Journal of Molecular Sciences (Mar-29) DOI: 10.3390/ijms22073546 - Evaluation of glial cell proliferation with non-invasive molecular imaging methods after stroke
Joya, Ana; Martin, Abraham
Neural Regeneration Research (Mar-25) DOI: 10.4103/1673-5374.310681 - Snapshot of microglial physiological functions
Verkhratsky, A.; Sun, D.; Tanaka, J.
Neurochemistry International (Mar-20) DOI: 10.1016/j.neuint.2021.104960 - Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity
Popov, Alexander; Brazhe, Alexey; Denisov, Pavel; Sutyagina, Oksana; Li, Li; Lazareva, Natalia; Verkhratsky, Alexei; Semyanov, Alexey
Aging Cell (Mar-20) DOI: https://doi.org/10.1111/acel.13334 - Δ9-Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo
Huerga‐Gómez, Alba; Aguado, Tania; Torre, Aníbal Sánchez-de la; Bernal‐Chico, Ana; Matute, Carlos; Mato, Susana; Guzmán, Manuel; Galve‐Roperh, Ismael; Palazuelos, Javier
Glia (Mar-15) DOI: 10.1002/glia.23911 - Oligodendroglial Energy Metabolism and (re)Myelination
Tepavčević, Vanja
Life (Mar-13) DOI: 10.3390/life11030238 - (Review) RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
Blanco-Urrejola, Maite; Gaminde-Blasco, Adhara; Gamarra, María; de la Cruz, Aida; Vecino, Elena; Alberdi, Elena; Baleriola, Jimena
Cells (Mar-12) DOI: 10.3390/cells10030632 - Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging
Arango, Juan Manuel; Padro, Daniel; Blanco, Jorge; Lopez-Fernandez, Sonia; Castellnou, Pilar; Villa-Valverde, Palmira; Ruiz-Cabello, Jesús; Martin, Abraham; Carril, Mónica
ACS Applied Materials & Interfaces (Mar-11) DOI: 10.1021/acsami.1c01291 - BASP1 labels neural stem cells in the neurogenic niches of mammalian brain
Manganas, Louis N.; Durá, Irene; Osenberg, Sivan; Semerci, Faith; Tosun, Mehmet; Mishra, Rachana; Parkitny, Luke; Encinas, Juan M.; Maletic-Savatic, Mirjana
Scientific Reports (Mar-10) DOI: 10.1038/s41598-021-85129-1 - (Review) Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways
Preman, Pranav; Alfonso-Triguero, Maria; Alberdi, Elena; Verkhratsky, Alexei; Arranz, Amaia M.
Cells (Mar-04) DOI: 10.3390/cells10030540 - (Review) Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery
Hampel, Harald; Vergallo, Andrea; Caraci, Filippo; Cuello, A. Claudio; Lemercier, Pablo; Vellas, Bruno; Giudici, Kelly Virecoulon; Baldacci, Filippo; Hänisch, Britta; Haberkamp, Marion; Broich, Karl; Nisticò, Robert; Emanuele, Enzo; Llavero, Francisco; Zugaza, José L.; Lucía, Alejandro; Giacobini, Ezio; Lista, Simone
Neuropharmacology (Mar-01) DOI: 10.1016/j.neuropharm.2020.108081 - Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Franco-Iborra, S.; Plaza-Zabala, A.; Montpeyo, M.; Sebastian, D.; Vila, M.; Martinez-Vicente, M.
Autophagy (Feb-28) DOI: 10.1080/15548627.2020.1728096 - The Absence of the Transient Receptor Potential Vanilloid 1 Directly Impacts on the Expression and Localization of the Endocannabinoid System in the Mouse Hippocampus
Egaña-Huguet, Jon; Bonilla-Del Río, Itziar; Gómez-Urquijo, Sonia M.; Mimenza, Amaia; Saumell-Esnaola, Miquel; Borrega-Roman, Leire; García del Caño, Gontzal; Sallés, Joan; Puente, Nagore; Gerrikagoitia, Inmaculada; Elezgarai, Izaskun; Grandes, Pedro
Frontiers in Neuroanatomy (Feb-22) DOI: 10.3389/fnana.2021.645940 - Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
Delgado, Diego; Bilbao, Ane Miren; Beitia, Maider; Garate, Ane; Sánchez, Pello; González-Burguera, Imanol; Isasti, Amaia; López De Jesús, Maider; Zuazo-Ibarra, Jone; Montilla, Alejandro; Domercq, María; Capetillo-Zarate, Estibaliz; García del Caño, Gontzal; Sallés, Joan; Matute, Carlos; Sánchez, Mikel
International Journal of Molecular Sciences (Feb-09) DOI: 10.3390/ijms22041725 - Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia
Reich, M.; Paris, I.; Ebeling, M.; Dahm, N.; Schweitzer, C.; Reinhardt, D.; Schmucki, R.; Prasad, M.; Köchl, F.; Leist, M.; Cowley, S.A.; Zhang, J.D.; Patsch, C.; Gutbier, S.; Britschgi, M.
Frontiers in Immunology (Feb-03) DOI: 10.3389/fimmu.2020.617860 - Astrocytes in heavy metal neurotoxicity and neurodegeneration
Li, B.; Xia, M.; Zorec, R.; Parpura, V.; Verkhratsky, A.
Brain Research (Feb-01) DOI: 10.1016/j.brainres.2020.147234 - GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties
Ordaz, R.P.; Garay, E.; Limon, A.; Pérez-Samartín, A.; Sánchez-Gómez, M.V.; Robles-Martínez, L.; Cisneros-Mejorado, A.; Matute, C.; Arellano, R.O.
Molecular pharmacology (Feb-01) DOI: 10.1124/molpharm.120.000091 - Satellite Glial Cells and Astrocytes, a Comparative Review
Hanani, M.; Verkhratsky, A.
Neurochemical Research (Feb-01) DOI: 10.1007/s11064-021-03255-8 - The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature
Chen, B.; Zhang, M.; Ji, M.; Gong, W.; Chen, B.; Zorec, R.; Stenovec, M.; Verkhratsky, A.; Li, B.
Neurochemical Research (Feb-01) DOI: 10.1007/s11064-020-03225-6 - Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover
Plaza-Zabala, Ainhoa; Sierra-Torre, Virginia; Sierra, Amanda
Frontiers in Immunology (Jan-29) DOI: 10.3389/fimmu.2020.620602 - Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments
Satta, V.; Alonso, C.; Díez, P.; Martín-Suárez, S.; Rubio, M.; Encinas, J.M.; Fernández-Ruiz, J.; Sagredo, O.
Frontiers in Molecular Neuroscience (Jan-29) DOI: 10.3389/fnmol.2020.602801 - Dopaminergic denervation impairs cortical motor and associative/limbic information processing through the basal ganglia and its modulation by the CB1 receptor
Antonazzo, M.; Gomez-Urquijo, S.M.; Ugedo, L.; Morera-Herreras, T.
Neurobiology of Disease (Jan-15) DOI: 10.1016/j.nbd.2020.105214 - Nanostructured scaffolds based on Bioresorbable polymers and Graphene oxide induce the aligned migration and accelerate the neuronal differentiation of neural stem cells
Polo, Y.; Luzuriaga, J.; Iturri, J.; Irastorza, I.; Toca-Herrera, J. L.; Ibarretxe, G.; Unda, F.; Sarasua, J. R.; Pineda, J. R.; Larrañaga, A.
Nanomedicine: Nanotechnology, Biology and Medicine (Jan-15) DOI: 10.1016/j.nano.2020.102314 - Mens sana in corpore sano: Lifestyle changes modify astrocytes to contain Alzheimer's disease
Augusto-Oliveira, M.; Verkhratsky, A.
Neural Regeneration Research (Jan-07) DOI: 10.4103/1673-5374.303023 - The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits
Reus-García, M. Mar; Sánchez-Campusano, Raudel; Ledderose, Julia; Dogbevia, Godwin K.; Treviño, Mario; Hasan, Mazahir T.; Gruart, Agnès; Delgado-García, José M.
Cerebral Cortex (Jan-05) DOI: 10.1093/cercor/bhaa225 - (Editorial) Stem and Cancer Stem Cell Identities, Cellular Markers, Niche Environment and Response to Treatments to Unravel New Therapeutic Targets
Pineda, Jose R.; Badiola, Iker; Ibarretxe, Gaskon
Biology (Jan-02) DOI: 10.3390/biology10010025 - Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; [...]; Nogueira-Recalde, Uxía; Nolan, Trevor M.; N
Autophagy (Jan-02) DOI: 10.1080/15548627.2020.1797280 - Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach
Llavero, Francisco; Alejo, Lidia B.; Fiuza-Luces, Carmen; López Soto, Alejandro; Valenzuela, Pedro L.; Castillo-García, Adrián; Morales, Javier S.; Fernández, David; Aldazabal, Itziar Pagola; Ramírez, Manuel; Santos-Lozano, Alejandro; Zugaza, José L.; Lucia, Alejandro
Exercise Immunology Review (Jan-01) pubmed.ncbi.nlm.nih.gov/33965896/
Other publications Latest | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012-2013