Inicio » Directory » Mariana Astiz Cadenas

Mariana Astiz Cadenas

Principal Investigator

Ikerbasque Research Professor

Mariana Astiz Cadenas


Correo electró

Tel.:(+34) 94 601 8160

Science Park UPV/EHU, Sede building
B. Sarriena, s/n
E-48940 Leioa

About me

 I am currently an Ikerbasque Research Professor, leading the Circadian physiology of neurons and glia laboratory. From the very beginning of my research career I felt extremely curious about biochemical aspects of the nervous system, especially in relation to the environment. By the end of my PhD at University of La Plata, Argentina and my first postdoc at Instituto Cajal, Madrid, Spain, I became particularly interested in pregnancy and how the environment, so early in life, is able to shape the offspring’s brain functions in the long-term. I joined the Institute of Neurobiology at the University of Lübeck, Germany in 2015 and became a junior group leader funded by DFG (German Research Foundation) in 2018. Since then, I have focused on the impact of the early environment on the development of the circadian system. My lab aims to understand which cells (neurons/astrocytes), signals (maternal/fetal) and mechanisms are important for the development of the central clock in the hypothalamic suprachiasmatic nuclei which will allow, later in life, the essential task of anticipating and adapting our physiology to daily changes in the environment.


  1. Estrogen-mediated coupling via gap junctions in the suprachiasmatic nucleus

    Schlaeger, Lina; Olejniczak, Iwona; Lehmann, Marianne; Schmidt, Cosima Xenia; Astiz, Mariana; Oster, Henrik; Pilorz, Violetta
    European Journal of Neuroscience (Apr, 2024) DOI: 10.1111/ejn.16270
  2. Ontogeny of the circadian system: a multiscale process throughout development

    Comas, Maria; De Pietri Tonelli, Davide; Berdondini, Luca; Astiz, Mariana
    Trends in Neurosciences (Jan, 2024) DOI: 10.1016/j.tins.2023.11.004
  3. Prenatal androgenization triggered neuroimmune alterations in the fetal ovary and programmed its persisting dysfunction

    Bazzano, Maria Victoria; Hardardottir, Lilja; Shi, Wenqin; Cattan, Joanne; Arck, Petra C.; Bosurgi, Lidia; Köninger, Angela; Astiz, Mariana; Solano, Maria Emilia
    Journal of Reproductive Immunology (Sep, 2023) DOI: 10.1016/j.jri.2023.104066
  4. Circadian glucocorticoids throughout development

    Lehmann, Marianne; Haury, Katharina; Oster, Henrik; Astiz, Mariana
    Frontiers in Neuroscience (Apr, 2023) DOI: 10.3389/fnins.2023.1165230