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Federico N. Soria Lannes

Principal Investigator

Ramón y Cajal Fellow, Ikerbasque Research Fellow

Federico N. Soria Lannes


Correo electró

Tel.:(+34) 94 601 8362

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

After graduating in Argentina (2007), my doctoral thesis in the laboratory of Carlos Matute studied glutamate homeostasis in animal models of brain ischemia and multiple sclerosis.

During my postdoc (2014-2018) at the team of Dr. Erwan Bezard in Bordeaux (France), I co-developed super-resolution imaging techniques to analyze the extracellular compartment in animal models of Parkinson’s disease. These results (Soria et al., 2020 Nat Commun), unraveled the nanoscale organization of the brain extracellular space in pathology and described an unknown feedback loop between the extracellular matrix and microglia. This work set the founding stone for my current research at UPV/EHU and Achucarro, focused on the matrix-glia interplay in healthy, aging and pathological brain, using live imaging and fluorescence microscopy approaches in in vivo, ex vivo and 3D-in vitro paradigms.


  1. Astrocytes adjust the dynamic range of cortical network activity to control modality-specific sensory information processing

    Miguel-Quesada, C.; Zaforas, M.; Herrera-Pérez, S.; Lines, J.; Fernández-López, E.; Alonso-Calviño, E.; Ardaya, M.; Soria, F.N.; Araque, A.; Aguilar, J.; Rosa, J.M.
    Cell Reports (Aug, 2023) DOI: 10.1016/j.celrep.2023.112950
  2. Local diffusion in the extracellular space of the brain

    Tønnesen, Jan; Hrabĕtová, Sabina; Soria, Federico N.
    Neurobiology of Disease (Feb, 2023) DOI: 10.1016/j.nbd.2022.105981
  3. Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

    Beccari, Sol; Sierra-Torre, Virginia; [...] Plaza-Zabala, Ainhoa; Sierra, Amanda
    Autophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313
  4. Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function

    Arotcarena, Marie-Laure; Soria, Federico N.; Cunha, Anthony; Doudnikoff, Evelyne; Prévot, Geoffrey; Daniel, Jonathan; Blanchard-Desce, Mireille; Barthélémy, Philippe; Bezard, Erwan; Crauste-Manciet, Sylvie; Dehay, Benjamin
    Aging Cell (Mar, 2022) DOI: 10.1111/acel.13584
  5. Super-resolution STED microscopy in live brain tissue

    Calovi, S.; Soria, F.N.; Tønnesen, J.
    Neurobiology of Disease (Aug, 2021) DOI: 10.1016/j.nbd.2021.105420
  6. Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling

    Soria, Federico N.; Paviolo, Chiara; Doudnikoff, Evelyne; Arotcarena, Marie-Laure; Lee, Antony; Danné, Noémie; Mandal, Amit Kumar; Gosset, Philippe; Dehay, Benjamin; Groc, Laurent; Cognet, Laurent; Bezard, Erwan
    Nature Communications (Jul, 2020) DOI: 10.1038/s41467-020-17328-9
  7. Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

    Soria, Federico N.; Pérez-Samartín, Alberto; Martin, Abraham; Gona, Kiran Babu; Llop, Jordi; Szczupak, Boguslaw; Chara, Juan Carlos; Matute, Carlos; Domercq, María
    Journal of Clinical Investigation (Aug, 2014) DOI: 10.1172/JCI71886