Postdoctoral (R2, R3) position for ERC project hASTROCURE at Arranz Lab
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The Arranz Lab - Laboratory of Humanized Models of Disease at Achucarro Basque Center for Neuroscience, is seeking a Postdoctoral Researcher to join hASTROCURE, a project funded by the European Research Council (ref # ERC-2024-COG - 01171591). Our lab focuses on understanding the complex role of human astrocytes in Alzheimer’s disease (AD). Using cutting-edge stem cell technologies, humanized in vitro models, and chimeric mice, our research aims to dissect how human astrocytes contribute to AD onset and progression. We are part of a vibrant neuroscience community and collaborate closely with national and international partners. Interested? |
Summary Information
Profile for this position
- Culture, maintenance, and amplification of human induced pluripotent stem cells (hiPSCs), and derived neural progenitors and astrocytes.
- Design and perform experiments using hiPSC-derived astrocytes and other CNS cell types.
- Establish, maintain, and analyze chimeric mouse models of AD.
- Perform molecular, cellular and imaging assays (sample processing, immunofluorescence, microscopy, etc).
- Analyze and interpret data; prepare reports, manuscripts, and presentations.
- Desirable
- Prior experience with Alzheimer’s disease models and glia/astrocyte biology.
- Prior track record of peer-reviewed publications in relevant fields.
- Prior experience supervising students.
Contract
The successful candidate will focus on understanding the reactive states of human astrocytes, and how they contribute to AD, using humanized in vitro models and chimeric AD mice. The candidate will work closely with experts in bioinformatics & spatial omics. It is a full-time position, starting the 1st January 2026.
Elegibility
- A PhD and excellent academic record in Neuroscience, Cell Biology, Bioinformatics, or related field.
- Previous experience in hiPSC differentiation to neural cells and astrocytes, and in vivo work (mouse models).
- Programming experience (e.g., R, Python, MATLAB) and familiarity with relevant bioinformatics pipelines.
- Experience with sample processing, immunofluorescence, and microscopy.
- Strong analytical, quantitative and time-management skills.
- Good/excellent written and spoken English; ability to write scientific reports and papers.
- Strong motivation for learning; ability to work independently and as part of a team.
- Desirable:
- Prior experience with Alzheimer’s disease models and glia/astrocyte biology.
- Prior track record of peer-reviewed publications in relevant fields.
- Prior experience supervising students.
Application deadline
15 Nov, 2025
Expected contract starting date
01 Ene, 2026
How to apply
Please send the following documents written in English indicating “Postdoc candidate_Surname” to arranz_lab@achucarro.org:
- A detailed CV including list of publications/congress participation, statement of achievements (200 words), previous positions, the degree’s academic record and certificates (including animal experiments training).
- A cover letter explaining your research interests, relevant experience & how you would contribute to our lab.
- Contact details of 2-3 referees (including PhD supervisor).