The main objective of the group is the in-depth study of the molecular bases of neurodegeneration and neuroprotection. More specifically, we investigate how neurons and glial cells die following insults which are relevant to neurological diseases including Alzheimer´s disease, multiple sclerosis and brain ischemia. To that end, we use experimental paradigms in vitro and in vivo in which we alter glutamate and ATP homeostasis, as well as the cannabinoid system, to activate signaling cascades and discover new mechanisms leading to cell death and how to prevent it. In turn, we also study how?-amyloid, a major pathogenic agent in Alzheimer’s disease, signals to neurons and glia and causes their demise. In addition, we are investigating the mechanisms underlying white matter damage in axons and oligodendrocytes in experimental ischemia and in animal models of multiple sclerosis. These activities are relevant to the discovery of new molecular targets that can be exploited for the development of new therapies with drugs. Moreover, we are also examining the potential of neurogenesis, as an endogenous mechanism to repair ongoing damage, and learning how to implement it for ameliorating brain function after injury.
In vitro models of neurotoxicity; Animal models of disease; Postmortem brain tissue from neurodegenerative diseases; and biological samples from patients in collaboration with neurologists and psychiatrists.
Cellular and molecular neurobiology; Electrophysiology; Calcium imaging; Immunochemistry; Light and electron microscopy; and Genotyping and functional genomics
Eneritz López Muguruza
Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during developmentNeuron (Jan, 2023) DOI: 10.1016/j.neuron.2022.10.032
Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitisCell Death & Disease (Jan, 2023) DOI: 10.1038/s41419-023-05551-3
Characterization of microglia behaviour in healthy and pathological conditions with image analysis toolsOpen Biology (Jan, 2023) DOI: 10.1098/rsob.220200
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagyAutophagy (Jan, 2023) DOI: 10.1080/15548627.2023.2165313
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changesGlia (In press) DOI: 10.1002/glia.24348
Spatial organization of neuron–astrocyte interactions in the somatosensory cortexCerebral Cortex (In press) DOI: 10.1093/cercor/bhac357
Oligodendrocyte progenitor cell recruitment and remyelination in multiple sclerosis: the more, the merrier?Brain (Dec, 2022) DOI: 10.1093/brain/awac307
GABAB receptor agonist baclofen promotes central nervous system remyelinationGlia (Dec, 2022) DOI: 10.1002/glia.24262
Shedding light on the etiology of neurodegenerative diseases and dementia: the exposome paradigmnpj Mental Health Research (Nov, 2022) DOI: 10.1038/s44184-022-00018-3
Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouseFrontiers in Neuroanatomy (Oct, 2022) DOI: 10.3389/fnana.2022.1030060