Joint application for a Postdoctoral fellowship in Glial role in Parkinson's disease

Summary Information

Category: Postdoctoral fellowship, Marie Skłodowska-Curie actions 2020, Individual Fellowship
Type of Contract: 24 months
Working Hours: 40 hours/week
Salary: Established by the MSCA actions
Location: Leioa, Spain
Deadline: September 9, 2020
Job Starting Date: March 1, 2021.
How to apply: Send an updated CV, a motivation letter and the contact details of 2 referees to fabio.cavaliere@ehu.eus indicating in the subject of the message: MCSA-IF 2020

Job Summary

The Laboratory of Neurobiology of ACHUCARRO is looking for a highly-motivated researcher of any nationality interested in applying for the Marie Skłodowska-Curie Actions (MSCA) Individual Fellowship call 2020 (H2020-MSCA-IF-2020). The candidate must have solid background on cellular biology, histology, pre-clinic investigation and be willing to learn new techniques and multidisciplinary concepts beyond the barriers between biology. Depending on the competitiveness of the researcher other joint applications/calls can be discussed and foreseen. Candidates must comply with the SPECIFIC REQUIREMENTS of the present offer, including the APPLICATION PROCEDURE.

Job Description

This research program aims to determine the role of glia, especially astrocytes, in the onset and progression of Parkinson's disease (PD). Glia participate to the dopaminergic neurodegeneration especially as the main player responsible for the process of neuroinflammation. However, their role (within the context of PD) in the propagation of proteopathic seeds, clearance of toxic molecules, or as metabolic support to burdened neurons, is uncertain. For example, the substantia nigra has a surprisingly low number of astrocytes in comparison to other heavy neuronal-loaded regions, and thus any astrocytic dysfunction in this region may result in neuronal stress and contribute to cell death.

The study of post-mortem brain tissue may provide a partial picture about the participation of glia in the degenerated areas. Therefore, we decided to implement our investigation with human iPSc-derived glia and 3D mixed cultures as models to study the physiology and metabolism of glia derived from PD patients and healthy donors.

The proposed research will combine different -omics approaches, morphological analysis using machine learning techniques and correlative studies with the clinical and histopathological profile of the patients.

The candidate is expected to have a solid background on cellular biology, histology, pre-clinic investigation and be willing to learn new techniques and multidisciplinary concepts beyond the barriers between biology, mathematics and pre-clinical studies. The candidate should be motivated, self-driven and be able to work independently and to integrate in a collaborative team. The candidate will be mentored and nurtured in a thrilling, young and international environment.

Host Laboratory

The Laboratory of Neurobiology is composed of several members including senior researchers, postdocs and PhD students and has a remarkable track record of publications and funding. ACHUCARRO is a young and international center, one of the Basque Excellence Research Centers and provides outstanding research opportunities.

Specific Requirements

  • Candidates must comply with the standard mobility rule of the MSCA IF 2020 call: The researcher cannot have resided or carried out his/her main activity (work, studies, etc.) in SPAIN for more than 12 months in the three years immediately before 09/09/2020 (MSCA call deadline). NOTE: Exceptional situations or career breaks can be taken in consideration, if a justification is provided.
  • Candidates must be in possession of a doctoral degree or have at least four years of full-time equivalent research experience by 09/09/2020 (call deadline).
  • NO age or nationality restrictions for the present offer.
  • The candidate must be available to work in the MSCA proposal application during August and the first week of September 2020, considering that the call deadline is 09/09/2020
  • Candidates must send an updated CV, a motivation letter and the contact details of 2 referees to fabio.cavaliere@ehu.eus indicating in the subject of the message: MCSA-IF 2020 by 01/06/2020 17:00
  • Detailed information on the MSCA IF Call 2020 available at the Participant Portal.

About Achucarro

Achucarro Basque Center for Neuroscience (ACHUCARRO) is a Basque Excellence Research Center (BERC) created by the Basque Government in 2012. Since 2017 this center is located in a new building in the Science Park of in Leioa, the main campus of the public University of the Basque Country (UPV/EHU), that provides cutting-edge facilities. The center has been awarded by the European Commission with the HR Excellence in Research to his commitment with the European charter for researchers and the code of conduct for the recruitment of researchers.

Achucarro commits to the principles laid down in the European Commission's Recommendation (March 11, 2005) for the European Charter for Researchers (The Code of Conduct for the Recruitment of Researchers).