Joint application for a Postdoctoral fellowship in Adult Hippocampal Neurogenesis

Summary Information

Category: Postdoctoral fellowship, Marie Skłodowska-Curie actions 2019, Individual Fellowship
Type of Contract: 24 months
Working Hours: 40 hours/week
Salary: Established by the MSCA actions
Location: Leioa, Spain
Deadline: August 15, 2019
Job Starting Date: April, 1 2020.
How to apply: Send an updated CV, a motivation letter and the contact details of 2 referees to jm.encinas@ikerbasque.org indicating in the subject of the message: MCSA-IF 2019

Job Summary

The laboratory of Neural Stems Cells and Neurogenesis at ACHUCARRO (led by Prof. Juanma Encinas) is looking for a highly-motivated researcher of any nationality interested in applying for the Marie Skłodowska-Curie Actions (MSCA) Individual Fellowship call 2019 (H2020-MSCA-IF-2019).

The candidate must have an electrophysiology background and willing to learn Dynamic Patch-Clamp to analyse with an unprecedented level of resolution the properties of hippocampal newborn generated in epilepsy and traumatic brain injury mouse models.  Depending on the competitiveness of the researcher other joint applications/calls can be discussed and foreseen.

Candidates must comply with the SPECIFIC REQUIREMENTS of the present offer, including the APPLICATION PROCEDURE.

Job Description

This research program proposes to study for the first time and with an unprecedented level of resolution, the dynamic modification of ion-channel function and the transition of the excitability processes as a postnatal/adult newborn dentate gyrus granule neurons develop towards maturation. Further, the analysis will be done using mouse models of epilepsy and traumatic brain injury (TBI) which with we have been working for several years.  Immature granule cells integrate and must adapt their intrinsic electrical properties to the existing neural circuit modifying physiologically the overall circuit function. But newborn neurons are sensitive to niche alterations (hyperexcitation, neuroinflammation) in which case their altered properties (aberrant neurogenesis) disrupt the overall circuit function. This is a complex (possibly multi-scale) phenomenon in which the granule cell undergoes a homeostatic non-synaptic plasticity (driven by the activity in the local environment) and finally synaptically integrates (via synaptic plasticity) into the local circuit.

The proposed research is the first study of its kind in which a full characterization of this process will contribute to the field of neurogenesis and in general to memory and learning, which impairment are hallmarks of epilepsy and TBI. To advance, we will follow a multidisciplinary approach by combining novel dynamic-clamp electrophysiology, mathematical modeling and advanced signal processing techniques. This is made possible as we bring together an inter-disciplinary team of researchers, which includes Neuroscientists (Experimentalists), Mathematicians and a Physicists.

The candidate is expected to have a solid background on electrophysiology and be willing to learn new techniques and concepts crossing the barriers between biology, mathematics and computational science. The candidate must be motivated, self-driven and be able to work independently. On the other hand the candidate must able to integrate in a collaborative team, and will be mentored and nurtured in a thrilling, young and international environment.

The host lab is composed of eleven team members including senior researchers, postdocs and PhD students and has a remarkable track record of publications and funding. ACHUCARRO is a young and international center, one of the Basque Excellence Research Centers and provides outstanding research opportunities.

The Basque Country offers impressive quality of life with unique combination of nature, culture and gastronomy.

Specific Requirements

  • Candidates must comply with the standard mobility rule of the MSCA IF 2019 call: The researcher cannot have resided or carried out his/her main activity (work, studies, etc.) in SPAIN for more than 12 months in the three years immediately before 11/09/2019 (MSCA call deadline). NOTE: Exceptional situations or career breaks can be taken in consideration, if a justification is provided.
  • Candidates must be in possession of a doctoral degree or have at least four years of full-time equivalent research experience by 11/09/2019 (call deadline).
  • NO age or nationality restrictions for the present offer.
  • The candidate must be available to work in the MSCA proposal application during August and the first week of September 2019, considering that the call deadline is 11/09/2019.
  • Candidates must send an updated CV, a motivation letter and the contact details of 2 referees to jm.encinas@ikerbasque.org indicating in the subject of the message: MCSA-IF 2019
  • Detailed information on the MSCA IF Call 2019 available at https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/opportunities/topic-details/msca-if-2019

About Achucarro

Achucarro Basque Center for Neuroscience (ACHUCARRO) is a Basque Excellence Research Center (BERC) created by the Basque Government in 2012. Since 2017 this center is located in a new building in the Science Park of in Leioa, the main campus of the public University of the Basque Country (UPV/EHU), that provides cutting-edge facilities. The center has been awarded by the European Commission with the HR Excellence in Research to his commitment with the European charter for researchers and the code of conduct for the recruitment of researchers. It hosts 35 senior and associate researchers developing research lines in the field of neuron-glia interactions in the normal and pathological brain, 10 postdocs, more than 10 technician/management personnel and provides training opportunities to about 30 PhD students. In the center, they have carried out many projects funded by the Basque Government, Spanish Government, European Union, etc. Since 2015, Achucarro as a whole has more than 200 scientific publications in prestigious international journals which have received nearly 4.000 cites. It is at the forefront in the field of neurosciences providing a multidisciplinary environment where several areas of expertise (medicine, biology, biochemistry and pharmacy) meet, creating a unique and internationally-recognized research center.

Achucarro commits to the principles laid down in the European Commission's Recommendation (March 11, 2005) for the European Charter for Researchers (The Code of Conduct for the Recruitment of Researchers).