{"version":"1.0","provider_name":"Achucarro Basque Center for Neuroscience","provider_url":"https:\/\/www.achucarro.org\/eu\/","title":"APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease pathology in chimeric mice - Achucarro Basque Center for Neuroscience","type":"rich","width":600,"height":338,"html":"<blockquote class=\"wp-embedded-content\" data-secret=\"Hb3mdur8DZ\"><a href=\"https:\/\/www.achucarro.org\/eu\/mintegia\/2024-02-joan-cruz-sese\/\">APOE3 and APOE4 human astrocytes differentially affect Alzheimer&#8217;s disease pathology in chimeric mice<\/a><\/blockquote><iframe sandbox=\"allow-scripts\" security=\"restricted\" src=\"https:\/\/www.achucarro.org\/eu\/mintegia\/2024-02-joan-cruz-sese\/embed\/#?secret=Hb3mdur8DZ\" width=\"600\" height=\"338\" title=\"&#8220;APOE3 and APOE4 human astrocytes differentially affect Alzheimer&#8217;s disease pathology in chimeric mice&#8221; &#8212; Achucarro Basque Center for Neuroscience\" data-secret=\"Hb3mdur8DZ\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\" class=\"wp-embedded-content\"><\/iframe><script>\n\/*! This file is auto-generated *\/\n!function(d,l){\"use strict\";l.querySelector&&d.addEventListener&&\"undefined\"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!\/[^a-zA-Z0-9]\/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret=\"'+t.secret+'\"]'),o=l.querySelectorAll('blockquote[data-secret=\"'+t.secret+'\"]'),c=new RegExp(\"^https?:$\",\"i\"),i=0;i<o.length;i++)o[i].style.display=\"none\";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute(\"style\"),\"height\"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):\"link\"===t.message&&(r=new URL(s.getAttribute(\"src\")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener(\"message\",d.wp.receiveEmbedMessage,!1),l.addEventListener(\"DOMContentLoaded\",function(){for(var e,t,s=l.querySelectorAll(\"iframe.wp-embedded-content\"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute(\"data-secret\"))||(t=Math.random().toString(36).substring(2,12),e.src+=\"#?secret=\"+t,e.setAttribute(\"data-secret\",t)),e.contentWindow.postMessage({message:\"ready\",secret:t},\"*\")},!1)))}(window,document);\n\/\/# sourceURL=https:\/\/www.achucarro.org\/wp-includes\/js\/wp-embed.min.js\n<\/script>\n","description":"Increasing evidence for a direct contribution of astrocytes as well as different APOE variants to Alzheimer\u2019s disease (AD) main pathological hallmarks comes from cellular and molecular studies in rodent models. Yet these models cannot fully mimic how human astrocytes affect AD pathology as human and rodent astrocytes differ considerably in morphology, functionality, and gene expression. [&hellip;]"}