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hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics

27 Mar 2023

Dr Amaia Arranz at ACHUCARRO and Dr Julia TCW at Boston University have leaded a perspective article about the use of human induced pluripotent stem cell (hiPSC) models to determine the contribution of human astrocytes to AD.

In this perspective piece, Arranz and TCW provide evidence supporting that:

  1. astrocyte biology is an important contributor early in AD;
  2. human iPSCs are an important tool for studying these astrocytes, and
  3. new therapies targeting astrocyte pathways may be efficacious in AD.
Human astrocytes get dysfunctional at early stages of AD and exacerbate the pathology affecting major AD processes. Combination of hiPSC-based in vitro and in vivo models with gene editing, multi-omics technologies and high-resolution imaging will allow in depth analyses of human astrocytes in AD and enable the development of astrocyte targeting therapeutics. Created with BioRender.com

This perspective has recently been published at Molecular Neurodegeneration.

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