1.0Achucarro Basque Center for Neurosciencehttps://www.achucarro.org/es/rich600338<blockquote class="wp-embedded-content" data-secret="aV8QyJOJLO"><a href="https://www.achucarro.org/es/seminar/2026-02-alvaro-larranaga/">Mitochondria-ER communication as a cellular health meter for neurodegeneration</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.achucarro.org/es/seminar/2026-02-alvaro-larranaga/embed/#?secret=aV8QyJOJLO" width="600" height="338" title="«Mitochondria-ER communication as a cellular health meter for neurodegeneration» — Achucarro Basque Center for Neuroscience" data-secret="aV8QyJOJLO" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script> /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); </script> Mitochondria–endoplasmic reticulum (ER) communication is organized through specialized contact sites (MERCS), which act as dynamic signaling platforms integrating many of the processes that fail early in neurodegeneration, including calcium handling, lipid homeostasis, organelle quality control, and stress adaptation. Rather than being passive structures, MERCS actively shape how cells respond to stress and can bias the […]