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Using humanized models to study the role of human astrocytes in Alzheimer’s disease

María Alfonso

Laboratory of Humanized Models of Disease, ACHUCARRO

16 Sep 2022 13:00

Aketxe Room, Sede Building, Leioa

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Recent studies highlight the importance of glial cells on the pathogenesis and progression of Alzheimer´s disease (AD). Among glial cells, it is well established that astrocytes undergo profound alterations in gene expression, morphology and function during the course of AD. However, such changes are still poorly defined and mostly unknown in the case of human astrocytes. To analyze human astrocyte responses and their contribution to AD we are using the stem cell technology and establishing humanized models in which human pluripotent stem cell (hPSC)-derived astrocytes are exposed to various AD-related challenges. Through various innovative assays we are studying human astrocyte reactivity and neurotoxic profiles and their capacity to uptake and degrade amyloid beta (Aβ). In sum, our approach allows exploration of human astrocytes on an AD context and will provide insights into their contribution to the pathophysiology of AD.

https://www.achucarro.org/laboratory/humanized-models-of-disease/