Seminarios Achucarro

21 Feb [2020]

at 13.00 CET

Brain organoids dissection into strategies for getting a better model for neurodevelopmental associated diseases

Lluís Cordón Barris

University of Southern California, Los Angeles

The neurodevelopmental disorders (NDDs) have a huge social and economic impact worldwide and among all of them the diagnosed cases of autism are dramatically increasing globally every year, having a prevalence of 1 out of 160 children. The autism is a wide spectrum disorder involving impairments in motor function, social interaction and a wide range of intellectual disability severities. The disease complexity including the diversity in genetic and environmental etiology, hinder the possibility to find a representative model for the NDDs.
GWAS studies continuously reveal new genes associated to autism and consequently the correspondent mouse models are used to further understand the mechanisms that leads to those pathologies. However, rodent models present some limitations that impede the translation of these results into an efficient, suitable and patient specific drug approach. In order to overcome these constraints and since the discovery of human inducible pluripotent stem cells (hIPSC), several groups had been attempting to create a brain organoid that recapitulates with high fidelity the neuronal diversity and transcriptional programs of the human brain development. Indeed, cortical organoids share cellular, transcriptomic and proteomic similarities with the human fetal brain and keep the evolutionary differences that distinguish humans from other mammals. However, cortical organoids are still a reductionist tool far from recapitulate with high fidelity the human brain development, central and peripheral nervous system connectivity and maturation.
For that reason, we purpose an optimization and high-throughput analysis of the data generated from both models to better characterize the neurodevelopmental disorders and consequently generate more efficient and specific therapies.

Host: Jorge Valero


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