Activation of damage-responsive Stem Cells in the adult fly brain
Stem cells and regenration laboratory of Champalimaud Center, Lisbon
Numerous adult tissues contain quiescent stem cells, which can be activated upon injury for tissue repair. In our research, we focus on injury-dependent control of stem cell activation to gain a mechanistic understanding of the injury-induced dynamic processes, which turn dormant stem cells into dividing progenitors. We have previously identified damage-responsive adult neural progenitor cells in the optic lobes of Drosophila, which - following acute injury - proliferate and form new neurons in the adult fly brain.
Our strategy is to use this genetically tractable model organism to study how stem cells are activated upon traumatic injury and contribute to regenerative neurogenesis. Using a combination of transcriptome profiling and functional genetic assays in vivo, we aim to identify and characterize novel regulators of damaged-induced neurogenesis to eventually test their potential in mammalian models of CNS injury. Furthermore, we are interested in how newly generated neurons efficiently integrate into the adult fly brain and may contribute to recovery of brain function using functional imaging of regenerated neurons and behavioral assays.
Host: Juan Manuel Encinas
This seminar is partially supported by the Campus of Biscay of the UPV/EHU.