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Carlos Matute

Principal Investigator

Carlos Matute


Correo electró

Tel.:(+34) 94 601 8286

Science Park of the UPV/EHU
Sede Building, 3rd floor, Barrio Sarriena, s/n
E-48940 Leioa Spain

About me

I did my PhD on chemical neuroanatomy of the visual pathway. Later on, I continued my training as postdoc at the Brain Research Institute in Zurich (1983-1986) on the use of tracers to reveal anatomical pathways, and the development of monoclonal antibodies to glutamate and GABA and its use in immunohistochemistry at the light and electron microscopic level. Then, I did a second postdoc (1986-1988) at the University of California, Irvine, studying glutamate receptors and their biochemistry and function. We then observed that gliomas and glial cells express these receptors.

After returning to Spain in 1988, I founded the Laboratory of Neurobiology at the University of País Vasco and followed up those initial studies by developing a new research line investigating the characterizing the neurotransmitter receptors present in glia (astrocytes, oligodendrocytes and microglia) as well as their functional and pathological relevance. Among other findings, we discovered that oligodendrocytes and myelin are highly vulnerable to glutamate and purinergic agonists, a feature which is relevant to multiple sclerosis and brain ischemia.

Currently I am Full Professor of Anatomy and Embriology. Member of the Academia Europaea since 2012.


  1. Alterations of Oligodendrocyte and Myelin Energy Metabolism in Multiple Sclerosis

    López-Muguruza, Eneritz; Matute, Carlos
    International Journal of Molecular Sciences (Aug, 2023) DOI: 10.3390/ijms241612912
  2. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

    Capelo-Diz, Alba; Lachiondo-Ortega, Sofía; [...] Martínez-Chantar, María Luz; Varela-Rey, Marta
    Cell Metabolism (Jul, 2023) DOI: 10.1016/j.cmet.2023.07.002
  3. 27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes

    Alanko, Vilma; Gaminde-Blasco, Adhara; Quintela-López, Tania; Loera-Valencia, Raúl; Solomon, Alina; Björkhem, Ingemar; Cedazo-Minguez, Angel; Maioli, Silvia; Tabacaru, Graziella; Latorre-Leal, María; Matute, Carlos; Kivipelto, Miia; Alberdi, Elena; Sandebring-Matton, Anna
    Glia (Jun, 2023) DOI: 10.1002/glia.24348
  4. Spatial organization of neuron–astrocyte interactions in the somatosensory cortex

    Baraibar, Andrés M; Belisle, Lindsey; Marsicano, Giovanni; Matute, Carlos; Mato, Susana; Araque, Alfonso; Kofuji, Paulo
    Cerebral Cortex (Apr, 2023) DOI: 10.1093/cercor/bhac357
  5. Therapeutic effect of α7 nicotinic receptor activation after ischemic stroke in rats

    Aguado, Laura; Joya, Ana; [...] Llop, Jordi; Martín, Abraham
    Journal of Cerebral Blood Flow & Metabolism (Mar, 2023) DOI: 10.1177/0271678X231161207
  6. GABAB receptor agonist baclofen promotes central nervous system remyelination

    Serrano-Regal, Mari Paz; Bayón-Cordero, Laura; Chara Ventura, Juan Carlos; Ochoa-Bueno, Blanca I.; Tepavcevic, Vanja; Matute, Carlos; Sánchez-Gómez, María Victoria
    Glia (Dec, 2022) DOI: 10.1002/glia.24262
  7. Cannabinoid CB1 receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse

    Manterola, A.; Chara, J.C.; Aguado, T.; Palazuelos, J.; Matute, C.; Mato, S.
    Frontiers in Neuroanatomy (Oct, 2022) DOI: 10.3389/fnana.2022.1030060
  8. GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes

    Bayón-Cordero, Laura; Ochoa-Bueno, Blanca Isabel; Ruiz, Asier; Ozalla, Marina; Matute, Carlos; Sánchez-Gómez, María Victoria
    Frontiers in Pharmacology (Jul, 2022) DOI: 10.3389/fphar.2022.897056
  9. Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

    Akwa, Yvette; Di Malta, Chiara; [...] Baulieu, Etienne E.; Tampellini, Davide
    Autophagy (Jul, 2022) DOI: 10.1080/15548627.2022.2095791
  10. Genetically modified macrophages accelerate myelin repair

    Aigrot, Marie-Stéphane; Barthelemy, Clara; Moyon, Sarah; Dufayet-Chaffaud, Gaelle; Izagirre-Urizar, Leire; Gillet-Legrand, Beatrix; Tada, Satoru; Bayón-Cordero, Laura; Chara, Juan-Carlos; Matute, Carlos; Cartier, Nathalie; Lubetzki, Catherine; Tepavčević, Vanja
    EMBO Molecular Medicine (Jul, 2022) DOI: 10.15252/emmm.202114759