Achucarro Seminars

24 Sep [2021]

at 13.00 CET

Exercise-conditioned Plasma Transfusions Increase Neuroplasticity, Improve Learning and Memory, and Reduce Neuroinflammation

Zuriñe de Miguel

California State University Monterey Bay and Stanford University (USA)


Physical activity evokes profound physiological responses and it is widely accepted and promoted as a method of improving human health, including brain health. Exercise interventions in people of various ages with or without neurodegenerative diseases, or brain damage, have been shown to improve cognitive function. Neuroinflammation is a common feature of these conditions and a potential mediator of the cognitive impairment associated with them. Studies in mouse models of aging and neurodegenerative diseases, such as AD and Parkinson disease have linked long-term voluntary wheel running with improved learning and memory, and decreased neuroinflammation. However, how exercise exerts these beneficial effects on the brain is poorly understood. It is possible that the physical exertion of muscle or lung during exercise may result in the secretion of factors from these or other tissues which subsequently signal to the brain. With this presentation, I will show that "runner" plasma, collected from mice with free access to running wheels and infused into sedentary mice, is sufficient to recapitulate the well-documented increase in neurogenesis and cognitive improvement induced by exercise. Moreover, we discovered that runner plasma infusions improve reduce neuroinflammation via clusterin. These findings demonstrate the existence of prominent anti-inflammatory "exercise factors" which are transferrable and benefit the brain.

Currently we are hosting our seminar in Zoom. The link is available to external people on request.


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