Neuron-oligodendroglia interactions in the construction and function of cortical circuits
María Cecilia Angulo
Paris Descartes University (France)
Myelination is a critical process required for speeding up action potential conduction and providing physical and metabolic support to axons of vertebrates. In the CNS, myelin sheaths are produced by oligodendrocytes (OLs), a glial cell type generated by oligodendrocyte precursor cells (OPCs) during development. Interestingly, OPCs are the only non-neuronal cells of the CNS that are contacted by bona fide synapses from neurons, but the role of these neuron-glia synapses are still controversial. In addition, increasing evidence suggests that myelination is modulated by neuronal activity and experience allowing for an increased plasticity of neuronal networks.
Previous findings of the team demonstrated that OPCs receive a major synaptic input from GABAergic interneurons during postnatal development of the somatosensory cortex. In the first part of the seminar, I will describe our recent findings on the functional properties of cortical interneuron-oligodendroglia interactions and their impact on cortical circuit function and mouse behavior.
From another side, despite the low regenerative capacity of the CNS, a production of newly-formed OLs and a partial myelin repair can occur in demyelinating diseases such as Multiple Sclerosis. This OL and myelin regeneration depends partly on the ability of oligodendrocyte precursor cells (OPCs) to proliferate and differentiate into the site of damage. In the second part of the talk, I will present our findings showing how neuronal activity enhances both oligodendrgolia calcium signals and functional myelin repair in demyelinated lesions.
Currently we are hosting our seminar in Zoom. The link is available to external people on request.