Thrombosis, cardiovascular risk factors & dementia: from mice to humans
Spanish National Centre for Cardiovascular Research [CNIC] (Madrid, Spain)
Alzheimer's disease (AD) is the most common form of dementia with hallmarks such as amyloid plaques, tau tangles, inflammation, neurodegeneration, and cerebral atrophy. This disease also presents an important vascular component with neurovascular alterations, cerebral hypoperfusion and a pro-coagulant state that contribute to disease onset and progression. Cardiovascular risk factors are also known to increase the risk of developing AD and indeed cardiovascular disorders co-appear with this neurodegenerative disease during symptomatic stages.
Dr. Marta Cortes Canteli focuses her research on understanding this heart-brain connection in AD. On one side, she is working towards developing and finding diagnostic and therapeutic approaches to identify and normalize, respectively, the pro-coagulant state found in a substantial amount of AD patients. On the other side, she also studies whether there is an underlying connection between AD and cardiovascular disorders during the long asymptomatic phases of both pathologies.
Currently we are hosting our seminar in Zoom. The link is available to external people on request.