Achucarro Seminars

12 Feb [2021]

at 13.00 CET

Specific hippocampal interneurons shape consolidation of recognition memory

Edgar Soria-Gómez

Laboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, ACHUCARRO


A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically impacts on memory processes is scantly known. We find that a small subclass of type-1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission.

Mice lacking CB1Rin D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1R in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. The CB1R-mediated NOR and associated LTP facilitation involve the local control of GABAergic inhibition in a D1-dependent manner.

This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, thereby identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.

Currently we are hosting our seminar in Zoom. The link is available to external people on request.


CAL Import this event to your agenda