Achucarro Seminars

12 Feb [2021]

at 13.00 CET

Specific hippocampal interneurons shape consolidation of recognition memory

Edgar Soria-Gómez

Laboratory of Ultrastructural and Functional Neuroanatomy of the Synapse, ACHUCARRO


Abstract

A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically impacts on memory processes is scantly known. We find that a small subclass of type-1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission.

Mice lacking CB1Rin D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1R in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. The CB1R-mediated NOR and associated LTP facilitation involve the local control of GABAergic inhibition in a D1-dependent manner.

This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, thereby identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.


Currently we are hosting our seminar in Zoom. The link is available to external people on request.

 

https://www.achucarro.org/people/edgar-soria-gomez

 

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