Achucarro Seminars

05 Feb [2021]

at 13.00 CET

Shaping cortical circuit rhythms and function by myelination

Maarten H.P. Kole

Netherlands Institute of Neuroscience (Amsterdam, The Netherlands)  


Myelin sheaths determine the electrical properties of axons by reducing the local capacitive load causing a rapid saltatory propagation of action potentials and speeding of the conduction velocity 1. While oligodendroglial myelination across the white- and grey matter regions regulate spike arrival times there is emerging evidence that myelin exerts additional roles including metabolic supply and extracellular ion regulation, which affect the properties of spike generation as well as information processing 2,3. In this talk I will discuss our recent findings from in vitro and in vivo electrophysiological recordings of parvalbumin basket cell-layer 5 pyramidal neuron pairs, combined with optogenetically targeted activation in toxin-induced and genetic demyelination models. Together, the results reveal a striking contribution of parvalbumin interneuron myelination in regulating cortical rhythms. Myelin loss amplifies state-dependently slow theta rhythms, revealing a contribution of myelin to local circuit activity and memory formation.    

1. Cohen, C. C. H. et al. Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit. Cell 180, 311-322.e15 (2020).
2. Moore, S. et al. A role of oligodendrocytes in information processing. Nature communications 11, 5497 (2020).
3. Battefeld, A., Klooster, J. & Kole, M. H. P. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequ

Currently we are hosting our seminar in Zoom. The link is available to external people on request.



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