Role of Nutrients in Microglial Function
Neurocentre Magendie (Bordeaux)
My research focuses on the nutrient sensing by microglia in various pathophysiological contexts. Here, I will mainly discuss a new mechanism by which low maternal omega-3 intake alters the shaping of neural networks during neurodevelopment by disrupting microglia-mediated synaptic pruning in the hippocampus. Our data show that maternal dietary omega-3 deficiency increases microglial phagocytosis of synaptic elements in the developing hippocampus, through the activation of 12/15- lipoxygenase (LOX)/12-HETE signaling, which alters neuronal morphology and affects cognition in the postnatal offspring. These findings provide new insights into the mechanisms linking maternal nutrition to neurodevelopmental disorders.
Currently we are hosting our seminar in Zoom. The link is available to external people on request.