A role of Zn and Vesicular glutamate transporters in the communication between Axon and myelin
Advanced imaging unit of the Queen's University in Belfast, UK
Myelinated axon is a complex structure involved in pathology of stroke , dementia and demyelinated neurological disorders like multiple sclerosis. In this seminar I will discuss our findings regarding the molecular physiology of synapse-like communication between axon and myelin and focus on the molecular pathways of axonal vesicular glutamate release and myelinic glutamate receptors activation. Also I will present preliminary data related to the potential role of optic nerve axonal VGLUT1 in stroke and the role of zinc and zinc signaling pathways in myelin destruction in ischemic conditions. I will speculate about the potential role of axonal VGLUT1 and ZnT3 in myelin physiology and pathology and future research directions.
Host: Maria Domercq