Molecular control of sense of touch
Radboud University (The Netherlands)
Activity-dependent regulation of cortical representations is believed to be the neural basis of adaptive changes in sensation and perception. In this seminar, I will give an update on our progress in identifying the mechanisms that control sensory and neuronal processing of touch. Performing information theoretic analysis on the activity-dependent changes in the transcriptome and proteome, we will first nominate critical molecular players and pathways that drive activity-dependent changes in the somatosensory cortex. Focusing on the monoaminergic systems, we will then validate some of the identified molecules, and determine their contribution to the neuronal and sensory processing of touch during postnatal development and in adulthood. The results will argue that dopaminergic and serotonergic signaling powerfully shapes the integration of sensory information in a cell-type specific manner and propose circuit mechanisms that link the regulation of neuronal excitability to improved sensory perception in the somatosensory system.
Host: Mazahir Hasan