Different role of microglia and astrocytes in the onset and progression of nigrostriatal degeneration
Mari Cruz Rodríguez Oroz
University Clinic of Navarra and CIMA
I will explain the main research lines of our lab and then I will focus on the study of the role of glial activation in the dopaminergic death.
Neuroinflammation has been implicated in the physiopathology of Parkinson's disease (PD). Microglial and astrocyte activation is observed in the substantia nigra pars compacta (SNc) and striatum of PD patients and animal models of parkinsonsim but their role in the beginning and progression of PD is unknown.
We have studied the relationship between neuroinflammation and nigrostriatal degeneration in a rat model of progressive parkinsonism induced by overexpression of mutated human α-syn in the SNc. In this model, in vivo microglia activation studied by [18F] -DPA714 positron emission tomography (PET) and post mortem molecular markers of neuroinflammation and dopaminergic lesion have been assessed at different time points after the viral vector injection.
Activity partially supported by UPV/EHU.
Host: Carlos Matute