Tel: (+34) 94 601 81 35
Science Park of the UPV/EHU, Sede building
Barrio Sarriena, s/n
I did my PhD Thesis in X. Nicol's laboratory (Vision Institute, France). We developed a strategy enabling the study of the relationships between individuals in a population for the first time. I showed that cooperation between neighboring retinal neurons determine axonal arbor refinement in the thalamus (Louail et al., Cell Reports, 2020). I described that these interactions depend on cAMP signaling specifically in retinal ganglion cells. With my experience I have realized that many developmental processes shaping brain connectivity require dialogue between different cells and cell types. Hence, I believe elucidating the relationships between different brain cells is key to understand how such precise network can be formed.
Microglia are actively involved in neural connectivity development and respond to neuronal activity. One key question is how their identity as brain cells is established and maintained, once their progenitors enter the brain. While past research focused on innate genetic programs, I propose that the mature microglial phenotype is shaped by the surrounding neuronal activity.