Dr. Jekyll and Mr. Hyde: what changes in a stem cell to become malignant?
José R. Pineda wrote about his research for MappingIgnorance.org
Research in oncology advances very fast and currently machine-learning-based expert systems exist for the pathologist to support the diagnosis of tumors of unknown origin or even deep comprehension of the role of both immunotherapy and tumor heterogeneity in immune-tumor interactions.
However, a key aspect to better understand the problem at its roots is to gain basic knowledge about the changes that overcome in a healthy cell to transform into a cancerous cell. One of the best examples may be the case of stem cells. Stem cells are the paradigm of future cell therapy to regenerate tissues, however cancer-stem like cells are the utmost nightmare very difficult to treat and responsible for aggressive tumor relapses.