Mar 10

Astrocytes in Alzheimer's Disease

A review on their pathological significance and molecular pathways

This review article is fruit of the collaboration between different laboratories and researchers in Achucarro, with Dr. Pranav Preman at VIB-KU Leuven, Belgium.

Astrocyte morphologies in healthy and in Alzheimer's disease brains.

In this paper, the authors provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease. Authors also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease.