Sep 28

Biochemical Scissor against Parkinson's Disease

New collaborative work demonstrating that the molecular tweezer CLR01 can reduce the neuronal death occurring in PD.

A group of researchers of the Laboratory of Neurobiology at ACHUCARRO, in collaboration with the colleagues from University of Oxford and other European and American institutions, discovered that the molecular tweezer CLR01 can reduce the neuronal death occurring in Parkinson's Disease (PD).

PD is a progressive neurodegenerative disease characterized by stiffness, tremor and other disabling movement disorders usually appearing during the elderhood. The unusual aggregation of the protein α-synuclein contribute to Parkinson's disease pathogenesis, thus a clinical strategy to reduce the α-synuclein aggregation may be planned to reduce neuronal degeneration.

In this research work published in Nature Communication, the authors demonstrated that the molecule CLR01 can be used in human neurons and humanized animal model of Parkinson's disease, as a biochemical scissor to prevent and reduce the aggregated neurotoxic form of the a-synuclein. These results highlight CLR01 as a disease-modifying therapy for PD and support further clinical investigation.

This important finding, led in ACHUCARRO by Paula Ramos, Carlos Matute and Fabio Cavaliere is the fruit of 5 years of cooperation between researchers from the UPV/EHU, the University of Oxford and the University of Bordeaux within  the European COEN Pathfinder funding programme.