Personnel

Susana Mato's photo

Susana Mato

Senior Researcher

Research group: Laboratory of Neurobiology

Contact

Tel: (+34) 946 015 681

Faculty of Medicine and Nursery, Department of Neuroscience

Barrio Sarriena, s/n

E-48940 Leioa Spain

About me

ORCID  0000-0002-2005-9793   ResearchGate
 

Research Interest

Our research interest aims at understanding the function and dysfunction of brain endocannabinoid system in neurological and neuropsychiatric conditions, with a special emphasis in myelin diseases. Our specific research goals include the study of:

  • Oligodendroglia endocannabinoid system in myelin damage and repair
  • Endocannabinoid dependent-synaptic dysfunction in mouse models of Multiple Sclerosis
  • Role and therapeutic potential of MAGL and ABHD6 in the treatment myelin diseases
  • Therapeutic potential of CB1 receptor antagonists in Fragile X Syndrome
WOP | The Walk On Project Foundation My project "Evaluating the Therapeutic Potential of Endocannabinoid Hydrolysis Inhibitors in Myelin Diseases" is funded and supported by The Walk On Project Foundation

Experimental Approaches

  • In vivo and in vitro models of myelin damage and regeneration (experimental autoimmune encephalomyelitis/EAE, cuprizone administration,  excitotoxicity in primary oligodendrocyte cultures)
  • Electrophysiology in brain slices (extracellular field recording, patch-clamp in visualized cells)
  • Imaging (calcium imaging in cultured cells, confocal microscopy-based imaging)
  • Biochemistry (receptor and [35S]GTP? autoradiography, quantitative PCR, western blot)

Collaborators

  • Benjamin F. Cravatt (Pharmacological and genetic tools for ABHD6 blockade/The Scripps Research Institute, La Jolla, USA)
  • Beat Lutz (Transgenic mouse models for the study of CB1 receptors/Johannes Gutenberg University, Mainz, Germany)
  • Frank Kirchhoff (Transgenic mouse models for the study of oligodendrocytes and their precursors/University of Saarland, Homburg, Germany)
  • Olivier Manzoni (Striatal synaptic pathology in demyelination/Mediterranean Institute of Neurobiology, Marseille, France)
  • Carlos Matute (Mechanisms of white matter damage and repair/University of the Basque Country UPV-EHU, Leioa, Spain)
  • Andrés Ozaita (Neurobiology of CB1 receptors Fragile X Syndrome/Universidad Pompeu Fabra/Barcelona, Spain)